Abstract:AimTo investigate the relationship between blood pressure load, blood pressure variability and tumor necrosis factor-α (TNF-a) in prehypertensives.Methods100 normotensives and 105 prehypertensives were recruited, while 110 hypertensives were enrolled.24 h ambulatory blood pressure monitoring was carried out in the three groups, blood pressure load and variability was computed and TNF-a was measured respectively.ResultsTNF-a, blood pressure load during 24 h, daytime and nighttime in prehypertensives were higher than that in normotensives while lower than that in hypertensives (p<0.01).Blood pressure variability during 24 h, daytime and nighttime in prehypertensives were higher than that in normotensives (p<0.05).The systolic blood pressure variability during 24 h and daytime and the diastolic blood pressure variability during 24 h and night in prehypertensives were lower than that in hypertensives (p<0.05).Pearson correlation analysis and multiple linear stepwise regression showed that the level of TNF-α was positively correlated with the systolic blood pressure load during 24 h and daytime, the diastolic blood pressure load during 24 h and nighttime, the systolic blood pressure variability during 24 h and nighttime (p<0.05).The systolic blood pressure load during 24 h and nighttime as well as systolic blood pressure variability during 24 h and nighttime were risk factors for TNF-a (p<0.01).ConclusionsBlood pressure load and blood pressure variability was correlated with TNF-a.Inflammation was relevant to the level of blood pressure in prehypertensives.

Abstract:Aim To observe the change of large arterial compliance and carotid atherosclerosis,explore the correlation between them in prehypertensive people.Methods 300 subjects each with prehypertension,high and normal blood pressue were selected randomly,and brachial-ankle pulse wave velocity (BaPWV),ankle-brachial index (ABI),carotid arteries intima media thickness (IMT) and plaque were observed.Results (1)BaPWV accelerates as the blood pressure elevate,prehypertensive group(1 390±171 cm/s) increased than in the normal group(1 293±151 cm/s,P<0.01),lower than the hypertensive group((1 652±291 cm/s,P<0.01);ABI in prehypertensive group(1.115±0.060) compared with normal blood pressure(1.114±0.061) had no difference,lower than in hypertensive group (1.132±0.067,P<0.01).(2) IMT thickening and plaque rate in prehypertension group compared with normal blood pressure group showed no statistical difference,but lower than the hypertensive group (P<0.01).Carotid common arteries IMT (CCA-IMT) in prehypertension(0.73±0.10 mm)and normal blood pressure group(0.72±0.12 mm)had no statistical difference,which were significantly thickened in high blood pressure group(0.78±0.16 mm,P<0.01).(3)PWV in people with carotid plaque increased than normal controls,in each subgroup (P<0.01).BaPWV was positively related to CCA-IMT(r=0.271,P<0.01),after adjustment of blood pressure the correlation still exists(r=0.156,P<0.01).Conclusion In prehypertension,arterial stiffness indicator BaPWV significantly increased,suggesting the existence of