Abstract:Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT), is considered as one of the most common cardiovascular diseases in the world, causing a huge social and economic burden. Despite the predominant role in the treatment of VTE, anti-thrombotic therapy has an extremely high risk of bleeding due to its association with blood coagulation and hemolysis system. Therefore, strict monitoring should be performed during the disease progression. However, the existing approaches can not fully meet the needs of precision medicine. Molecular imaging can reflect the disease information at the molecular level. Quantitative monitoring on thrombus-targeted nanoprobes through imaging approaches can accurately diagnose disease subtypes and provide personalized treatment. This article reviews the research progress of nanomolecular imaging in the diagnosis and treatment of VTE in recent years, which is expected to provide new ideas for the diagnosis and treatment of VTE.

Abstract:Structural vascular imaging throughout the body has advanced rapidly, and the atherosclerotic stenosis and plaque could be visualized as well as qualitatively and quantitively assessed. Multimodality imaging can improve cardiovascular and cerebral risk prediction by informing on the constituency and metabolic processes within the vessel wall. This review will provide an overview of current imaging techniques for the imaging of atherosclerotic disease.

Abstract:Cardiovascular disease, especially coronary atherosclerotic heart disease, is the main cause of death in China and the world. The occurrence of coronary atherosclerosis, plaque rupture and thrombosis, as well as myocardial injury and repair process after myocardial infarction are regulated by many complex cellular and molecular signal networks.The current clinical imaging methods can assess the anatomy and perfusion of the coronary artery and heart, but they cannot accurately reflect the pathophysiological process and progression of the disease. In recent years, the development of molecular imaging technology has made the visualization and quantification of cardiovascular diseases pathological processes possible. Therefore, it has important clinical value for accurate diagnosis and prognostic judgement of cardiovascular diseases which assists clinical decision-making. This review aims to summarize the current molecular imaging research progress of acute myocardial infarction.

Abstract:Cardiovascular disease is a serious threat to human life and health with accounting for more than 40% of the disease deaths in China, and its incidence has a tendency to rise. Therefore, it is important to develop new technologies and methods for the diagnosis and treatment of cardiovascular diseases. Nanotechnology is a novel discipline developed in this century, and it has brought new ideas and new methods together with the modern medicine, which established nanomedicine for the diagnosis and treatment of cardiovascular diseases, and with unique methods, it has already achieved a great significance in cardiovascular researches. This review focuses on recent advances in nanomedicine for the diagnosis and treatment of cardiovascular diseases.

Abstract:Stem-cell therapy may provide a novel therapeutic strategy for cardiovascular diseases as well as other degenerative diseases. A rapid transition from animal research to clinical trials is taking place. However,numerous issues remain unresolved,particularly the molecular mechanisms underlying potential therapeutic benefits of stem cells.