Abstract:Aim Association between the-1562C>T single nueleotide polymorphisms of matrix metalloprotein-9 gene and the occurrence coronary artery disease in Chinese Han population was studied. Methods Case-control studies published before 31 Dec.2010 about the association of matrix metalloprotein-9 gene-1562C>T polymorphism and coronary artery disease in Chinese Han population were searched,all the literatures were evaluated and abstracted based on the defined selection criteria by two independent investigators.Publication bias was tested by funnel plot and the odd ratios of all studies were combined dependent on the result of heterogeneity test among the individual studies.The software Review Manager(version 5.0) and Stata(version 10.0) were used for meta-analysis. Results Seven studies were analyzed,there was no publication bias in 7 reviewed studies.The summarized odds ratios of TT and CT genotype combination versus CC genotype across all 7 studies was OR= 1.47(95% CI was 1.20~1.78,P=0.0001);T genotype versus C genotype was OR=1.41(95% CI was 1.17~1.69,P=0.0002);CC genotype versus TT and CT genotype combination was OR= 0.68(95% CI was 0.55~0.82,P<0.0001);CT genotype versus CC and TT genotype combination was OR=1.45(95% CI was 1.19~1.77,P=0.0002). Conclusions In Chinese Han population,-1562C>T polymorphism in matrix metalloprotein-9 gene is associated with susceptibility of coronary artery disease and T allele might be a risk factor for coronary artery disease.

Abstract:Aim To investigate the role of peroxisome proliferator activated receptor-γ (PPAR-γ) in the regulation of matrix metalloproteinases (MMP-9) and tissue inhibitor of metalloproteinase (TIMP-1) expression by peripheral blood monocyte derived macrophages (MDM) in acute coronary syndrome (ACS) patients. Methods MDM were from patients with ACS and controls have been assigned to different subgroups and incubated by different concentrations of rosiglitazone. The concentrations of MMP-9 and TIMP-1 in the supernate of MDM and the expression strength of PPAR-γ,MMP-9 and TIMP-1 mRNA in MDM were analysed and compared between ACS group and control group,and among the different concentrations of rosiglitazone intervention subgroups. Results After rosiglitazone interventing,either in ACS group or in control group,PPAR-γ mRNA expression were significantly upward,and there were a positive correlation between the expression strength and rosiglitazone intervention concentration; both the MMP-9 concentration in the supernate and the expression strength of MMP-9 mRNA were descended,and there were negative correlation between the extent of its descent in the ACS group and rosiglitazone concentration. There was no significant change in TIMP-1 concentration in the supernate of MDM and TIMP-1mRNA expression after rosiglitazone interventing. Conclusion MDM had endogenous PPAR-γ receptor,and it could be activated by rosiglitazone. Rosiglitazone intervention significantly increased the expression of PPAR-γ of MDM,reduced the expression of MMP-9,particularly in the ACS group. TIMP-1 expression was not affected. There may be impact of stablizing atherosclerotic plaque.