Abstract:Aim To investigate the effect of combined enhanced exteral counterpulsation (EECP) therapy on blood lipids, inflammatory status, and cardiorespiratory function in patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI), under the premise of standardized drug treatment. Methods A total of 93 patients diagnosed with CHD and undergoing PCI surgery at Cardiovascular Department, the Second Hospital of Shanxi Medical University were selected for screening from June 2022 to December 2023. According to the patients treatment intention, they were randomly divided into control group and EECP group. The control group received simple drug treatment, while the EECP group received combined EECP treatment for 3 months on the basis of drug treatment. Blood lipids, monocyte to high density lipoprotein cholesterol ratio (MHR), neutrophil to lymphocyte ratio (NLR), and exercise endurance indicators were recorded and compared before and after treatment. Results After treatment, the patients in EECP group showed a 19.6% decrease in total cholesterol (TC), a 27.0% decrease in triglyceride (TG), a 25.0% decrease in low density lipoprotein cholesterol (LDLC), a 25.4% decrease in MHR, a 37.2% decrease in NLR, and a 6.7% increase in maximum exercise time, with statistical significance (P＜0.05). The treatment effect was better than that of the control group. Conclusion On the basis of standardized drug treatment, the combination of EECP treatment in patients with CHD after PCI can effectively reduce blood lipid levels, improve systemic inflammation, promote the improvement of motor function, and improve patients quality of life.

Abstract:Aim To explore the effect of enhanced external counterpulsation (EECP) against atherosclerosis and its endothelial mechanisms. Methods Twelve hypercholesterolemic pigs were randomly divided into the hyperlipidemia and EECP groups. After EECP,amount to 36 hours,the coronary arteries and abdominal aortas were sampled for histopathologic and ultrastructural examination. The endothelial cells (EC) were collected from thoracic aorta for proteomic study. Results Compared with the hypercholesterolemic animal receiving EECP,much more plaques were found in the hypercholesterolemic animal without EECP. The plaque/intimal area ratio of the aorta decreased significantly in animals receiving EECP (1.27%±0.35%) versus (7.83%±2.39%) in those without EECP,P<0.05. Lipid deposition,endothelial damage and proliferation of smooth muscle cells were less severe in animals receiving EECP than those without EECP. Moreover,eight kinds of proteins were higher expressed in ECs from animals receiving EECP than from those without EECP. Conclusion EECP could prevent atherosclerotic lesion progress by repairing damaged endothelia caused by hypercholesterolemia.