Abstract:Aim To evaluate the relativity of blood gamma-glutamyl transferase（GGT)level and intracranial and extracranial artery stenosis of cerebral infarction patients. Methods According to computerized tomography angiograph（CTA）, a total of 163 cerebral infarction inpatients were divided into intracranial and extracranial artery with or without stenosis group,the blood GGT levels and other risk factors were compared among groups. Results Artery stenosis groups had significantly higher age, male, smoking, hypertension, diabetes mellitus, triglyceride（TG）, GGT, low density lipoprotein（LDL)levels than those without intracranial and extracranial artery stenosis group（P<0.05）. The levels of blood GGT of pure extracranial artery stenosis group and simple intracranial stenosis group showed no significant difference（P>0.05）. An increase in blood GGT predicts the increasing degree of cranial atherosclerotic stenosis. Logistic regression analysis showed that GGT were indepent risk factors of intracranial and extracranial atherosclerotic stenosis（OR17.863,95%CI:2.583～123.520）,which showed statistic significance（P0.003）. Conclusion The blood level of GGT and cranial atherosclerotic stenosis are closely related. The concentration of GGT is associated with severity of intracranial or extracranial stenosis. GGT is a risk factor for the cranial stenosis and has no selectivity for intracranial or extracranial artery injury.

Abstract:Aim To study the cerebral hemodynamics and influencing factor by using multislice CT perfusion imaging in early acute cerebral infarction. Methods Seventeen patients doubted with cerebral infarction by routine CT scan with negative results underwent CTPI and CTA within 6 hours. CTPI with cerebral blood flow(CBF),cerebral blood volume(CBV) and time to peak(TTP) were observed and evaluated.All cases were followed-up with CT or MRI after 2 to 7 days. Results The CBF,CBV at gray and white matter in ischemic region were lower than that in opposite side in early acute cerebral infarction patients(P<0.05).The CBF at gray matter in opposite side in patients was lower than that in control group,the CBV,TTP at gray matter and CBF,TTP at white matter in opposite side in patients were higher than that in control group(P<0.05).The age of patients and the cerebral hemodynamics was correlated in early acute cerebral infarction patients(CBF r=-0.707,CBV r=-0.658) (P<0.05). Conclusion The cerebral hemodynamics were changed not only in ischemic region but also in opposite side in early acute cerebral infarction patients.The age of patients acts as an importment influencing factor in ischemic region in early acute cerebral infarction patients.