2020, 28(10):895-898.
Abstract:Aim To investigate the risk factors of depression in patients with hypertension. Methods 110 patients with hypertension combined with depression and 110 patients with hypertension alone were enrolled in this study,and the general data and serum factor levels of the two groups of patients were collected and compared. Multivariate Logistic regression analysis was performed on the variables with statistical significance in univariate analysis. Results Univariate analysis showed that cortisol(Cor)and renin precursor(Rep)levels were significantly increased and heme oxygenase-1(HO-1)levels were significantly decreased in patients with hypertension combined with depression (P<0.05), but there was no significant differences in other indicators between the two groups. Multivariate Logistic regression analysis was used to analyze the three variables selected by univariate analysis. It was found that HO-1 (OR=0.2,5%CI:0.001~0.251, P<0.01) and Rep(OR=5.9,5%CI:3.054~11.706, P<0.001) were the important risk factors of depression for patients with hypertension. Conclusion Low HO-1 level and high Rep level are the important risk factors of depression for patients with hypertension.
2017, 25(1):65-70.
Abstract:Aim To explore the relationship between cumulative heart rate exposure (cumHR) and brachial-ankle pulse wave velocity (baPWV). Methods A total of 7904 participants were selected from Kailuan Study stroke cohort and elderly population cohort to compose observation population, and finally 5153 cases were included in the study cohort. According to cumHR, the research subjects were divided into four groups. The correlation between cumHR and baPWV was analyzed by partial correlation analysis. The effects of cumHR on baPWV were analyzed by multivariate linear regression and multivariate Logistic regression. Results With the increase of cumHR, the average level of baPWV and the detection rate of baPWV≥1400 cm/s were on the rise. The results of partial correlation analysis showed that cumHR was positively correlated with baPWV (r=0.35, P<0.05), and after adjusting age and sex, cumHR was still positively correlated with baPWV (r=0.24, P<0.05). Multivariate linear regression analysis showed that cumHR increased by 1 beat/minute, baPWV increased 1.071 cm/s. Logistic regression analysis showed that after correction of other confounding factors, compared with the cumHR first group, cumHR second group, third group and fourth group were risk factors for baPWV≥1400 cm/s, and OR values (95%CI) were respectively 1.432 (1.121-1.829), 1.738 (1.371-2.204) and 2.475 (1.949-3.143). Conclusions cumHR is positively correlated with baPWV. cumHR is a risk factor for the increase of pulse wave velocity.
2017, 25(6):618-622, 634.
Abstract:Aim To explore the relationship between cumulative triglyceride exposure (cumTG) and ankle-brachial pulse wave velocity(BaPWV). Methods A total of 23499 participants was selected from Kailuan Study stroke cohort, hypertensive population and elderly population cohort to compose observation population, and finally 14662 cases were included in the study cohort. According to cumTG, the research subjects were divided into four groups. The correlation between cumTG and BaPWV was analyzed by partial correlation analysis. Multivariate linear regression and multivariate Logistic regression were used to analyze the effects of cumTG on BaPWV. Results With the increase of cumTG, the average BaPWV level and the detection rate of BaPWV≥ 1400 cm/s showed an increasing trend. The correlation analysis showed that cumTG was positively correlated with BaPWV (r=0.512, P<0.05), and cumTG was positively correlated with BaPWV (r=0.322, P<0.05) after adjustment for age and sex. Multivariate linear regression analysis showed an increase in BaPWV of 4.507 cm/s for each increase in cumTG. Logistic regression analysis showed that the cumTG second quartile, the third quartile, and the fourth quartile were significantly associated with BaPWV≥1400 cm/s compared with the cumTG first quartile after adjustment for other confounders (95%CI) which were 1.667(1.505~1.845), 2.384 (2.111~2.691) and 3.287(2.887~3.741), respectively. Conclusion cumTG is positively correlated with BaPWV.cumTG is a risk factor for the increase of pulse wave velocity.
2016, 24(2):193-197.
Abstract:Aim To analyze the clinical characteristics, interventional therapy effect and prognosis for the 70 patients with unprotected left main coronary artery(UPLM) lesion. Methods Clinical data of 70 patients who accepted the interventional therapy for UPLM lesion were collected from January 2012 to July 2013 in our hospital. Telephone or clinic follow-up was carried out after the operation. The clinical characteristics and effect of interventional therapy for patients were analyzed, and the related factors that influenced the clinical prognosis of interventional therapy were explored.Results The 70 patients included 74.3% male and 25.7% female. The average age was 69.30±9.95 years. The average of the left ventricular ejection fraction(LVEF) was 49.0%. The median value of the estimated glomerular filtration rate(eGFR) was 56 mL/(min·1.73 mm2). The average Syntax score was 26.5 and the median value of stents length was 34 mm. All patients were followed up for average of 13.3 months. The cumulative incidence of the major adverse cardiovascular event(MACE) estimated by Kaplan-Meier was 24.5%. No severe hemorrhage complication was observed after inteventional therapy. Univariate regression analysis with COX proportional hazards model revealed that the increase of LVEF would decrease the incidence of MACE(P=0.01), and the elevation of Syntax score would increase the incidence of MACE(P=0.03). Age≥70 years tended to increase the incidence of MACE(P=0.053), while the increase of eGFR tended to reduce the incidence of MACE(P=0.05). Multivariate regression analysis with COX proportional hazards model demonstrated that LVEF and eGFR had predictive value for the MACE(P=0.016 and P=0.17), while the predictive effect of Syntax score and age≥70 years were attenuated. Conclusions The interventional therapy of UPLM disease is effective and safe. The LVEF and eGFR are the major predictors of the MACE.
2004, 12(1):73-76.
Abstract:Aim To evaluate the correlation between three single nucleotide polymorphisms (SNPs) at -217,-20 and -6 locus in the promoter region of angiotensinogen (AGT) gene and myocardial infarction (MI) in south Han Chinese population. Methods ABI PRISM SNaPshot Multiplex Kit was used to genotyping G-217A, A-20C and G-6A polymorphisms in 216 patients with MI and 185 healthy controls. Results The AA, AG and GG genotypes of G-217A polymorphism were obviously different between group of MI and group of controls (10, 77 and 129 to 8, 37 and 140, P=0.002 ). Frequencies of A and G alleles were also significantly different between two groups (22.45%, 77.55% to 14.32%, 85.68%, P=0.003). The AA, AG and GG genotypes of G-6A polymorphism were obviously different between two groups (147, 64 and 5 to 127, 44 and 14, P=0.029). But, frequencies of A and G alleles of G-6A had no significant difference between two groups (P=0.394). The CC, AC and AA genotypes of A-20C polymorphism were different between two groups (6, 51 and 159 to 2, 61 and 122), but no statistical difference was found (P=0.067). Logistic regression analysis showed that age (P=0.001), systolic blood pressure (SBP) (P=0.013) and serum concentration of triglyceride (TG) (P=0.010) were all independent risk factors for MI. Serum concentration of high density lipoprotein-cholesterol (HDLC) (P=0.018) was a protective factor for MI. Conclusions G-217A and G-6A polymorphisms of AGT gene might be associated with the occurrence of myocardial infarction in south Han Chinese population.