Abstract:Protein palmitoylation is a kind of post-translational lipid modification of proteins that widely exists in organisms. Generally, S-palmitoylation occurs mainly through the covalent attachment of palmitic acid to protein-specific cysteine residues via labile thioester linkages. S-palmitoylation is usually reversible because the thioester bond will be hydrolyzed under certain conditions, causing protein depalmitoylation. In addition, S-palmitoylation is closely associated with the occurrence and development of many cardiovascular diseases. This review summarizes the process of protein palmitoylation and depalmitoylation, the relationship between protein palmitoylation and cardiovascular diseases, including arrhythmia, atherosclerosis, pulmonary hypertension, heart failure, and thrombotic diseases, which provide a new direction for cardiovascular disease treatment.

Abstract:Aim To evaluate the relationship between the levels of heparin binding epidermal growth factor(HB-EGF), phosphodiesterase 4D (PDE4D) in serum and acute coronary syndrome(ACS). Methods The protein levels of HB-EGF, PDE4D were measured in serum of 50 patients with ACS (ACS group) and 100 cases normal control (normal control group) by double antibodies sandwich ABC-ELISA method. The relationship between the protein levels and ACS was evaluated by logistic regression analysis. Results After correcting for meaningful factors such as high blood pressure, smoking, TG, TC, LDLC, HDLC and BMI by single factor analysis, it found that the protein level of HB-EGF was associated with whether or not suffering from ACS (OR=4.4,5%CI was 1.2,9.498, P=0.001). The protein level of PDE4D was associated with whether or not suffering from ACS, too (OR=5.9,5%CI was 1.4,4.448, P=0.003). Conclusion The protein levels of HB-EGF, PDE4D in serum was associated with whether or not suffering from ACS. Cases with high protein levels of HB-EGF, PDE4D were at high risk of ACS.

Abstract:DNA which extracted from embryo tissue of human exhibited esterase activity. The experimental results suggested that α-naphtyl or β-naphtylacetate could be decomposed by the DNA and then fastblue RR salt be led to appear special violet colour.

Abstract:DNA which extracted from embryo tissue of human exhibited esterase activity. The experimental results suggested that α-naphtyl or β-naphtylacetate could be decomposed by the DNA and then fastblue RR salt be led to appear special violet colour.