Abstract:Aim To investigate the longitudinal association between handgrip strength and risk of hypertension in the middle-aged and elderly population in China. Methods The participants aged 45 years and older were selected from the China health and retirement longitudinal study(CHARLS). Multivariate Logistic regression models or linear regression models were used to analyze the associations of handgrip strength with hypertension and blood pressure. In the primary analysis, the relative maximum handgrip strength (maximum handgrip strength/body mass index) was divided into three groups according to the tertiles. Results A total of 5 876 subjects were included in this study. After an average follow-up of 3.85 years, the incidence of hypertension was 19.11%. The incidence of hypertension was increased with the decreasing of handgrip strength (Ptrend＜0.05). The multivariate Logistic regression model showed that relative handgrip strength was negatively associated with the risk of hypertension after adjusting for general demographic, lifestyle, health status and other factors. The risk of hypertension in the high relative handgrip strength group was 46% (RR:0.4,5%CI:0.34～0.84, P＜0.01) and 59% (RR:0.1,5%CI:0.26～0.67, P＜0.01) lower than that in the low relative grip strength group for men and women, respectively. The systolic and diastolic blood pressure levels in high relative handgrip strength group were 3.03 mmHg and 1.33 mmHg (P＜0.05) lower than those in the low relative handgrip strength group for men, and were 4.48 mmHg and 1.92 mmHg (P＜0.05) lower than those in the low relative handgrip strength group for women. Conclusions The handgrip strength was longitudinally associated with the high risk of hypertension in middle-aged and elderly population. It suggested that handgrip strength may be a predictor of hypertension.

Abstract:Aim To explore the changes of the prevalence rate of blood pressure abnormality in Shanghai Bao-Steel Company-based population. Methods All medical records of the employees were analyzed,who underwent health examination biennially from 1995 to 2002.Systolic blood pressure(SBP) abnormality,diastolic blood pressure(DBP) abnormality and hypertension were diagnosed by SBP≥140 mmHg, DBP≥90 mmHg and SBP≥140 mmHg or DBP≥90 mmHg or administrated hypotensive drugs.SPSS 11.5 of statistical software was used for data analysis. Results During the study period,59 131 person-times received periodic medical check-up,of which 27.1% participants received four times check-up,and 26.6% three times,24.0% twice,respectively.The mean SBP increased from 115.7 mmHg to 123.6 mmHg,and the mean DBP increased from 76.8 mmHg to 83.0 mmHg.The standardization prevalence rates of SBP abnormality and DBP abnormality increased separately from 4.1% and 12.3% to 8.0% and 20.6%.The standardization prevalence rate of hypertension increased from(13.4%) to 23.6% from 1995 to 2000,then decreased to 20.1%.The standardization prevalence rates of SBP abnormality and DBP abnormality of the total increased with time.By the analysis of age and sex,it was found that the prevalence rate of SBP abnormality increased significantly with time in men younger than 60 years old and the prevalence rate of DBP abnormality increased significantly with time in men younger than 50 years old,but the prevalence rates of SBP abnormality and DBP abnormality were so only in women in 40～49 years old.No matter in the total or men or women younger than 60 years old,the prevalence rate of hypertension increased with time from 1995 to 2000,but decreased in 2001～2002.At the same time and the same age range the prevalence rate of blood pressure abnormality in men was higher than that in women.At the same time the prevalence rate of DBP abnormality was higher than that of SBP abnormality. Conclusion The prevalence rates of SBP abnormality and DBP abnormality were increasing in Bao-Steel Company employees,which occured mainly in the middle-age and young men.