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    • Association between triglyceride-glucose index and hypertension in middle-aged and older adults

      2024, 32(7):583-589.DOI: 10.20039/j.cnki.10073949.2024.07.005.

      Keywords:triglyceride-glucose index hypertension middle-aged and older adults
      Abstract (296)HTML (0)PDF 4.32 M (2945)Favorites

      Abstract:Aim To investigate the relationship between triglyceride-glucose (TyG) index and the risk of hypertension in middle-aged and older adults in China, and to provide scientific basis for the prevention and treatment of hypertension. Methods Data were obtained from the China health and retirement longitudinal study (CHARLS) in 2011. A multi-stage stratified sampling method was used to select participants. Restricted cubic spline regression model was used to analyze the dose-response relationship between TyG index and the risk of hypertension. Multivariate unconditional Logistic regression model was used to evaluate the association between TyG index and the risk of hypertension.Results A total of 9 987 subjects were included in the analysis, with an average age of (59.16±9.43) years, including 4 707 males (47.13%). The restricted cubic spline regression model showed that the risk of hypertension increased with the elevation of TyG index, and there was a linear association (overall association test P<0.000 1, non-linear association test P=0.201 9). The results of multivariate Logistic regression model showed that compared with Q1 (TyG index<8.23), the OR(95%CI) of hypertension with Q2 (8.23≤TyG index<8.59), Q3 (8.59≤TyG index<9.04) and Q4 (TyG index≥9.04), were 1.09 (0.95~1.26), 1.53 (1.33~1.76) and 1.77 (1.52~2.06), respectively. Conclusions With the increase of TyG index, the risk of hypertension gradually increased. TyG index may be an independent risk factor of hypertension.

    • Correlation of TyG and AIP indices with the severity of chronic coronary syndrome

      2024, 32(7):590-596.DOI: 10.20039/j.cnki.10073949.2024.07.006.

      Keywords:chronic coronary syndrome triglyceride-glucose index atherogenic index of plasma
      Abstract (237)HTML (0)PDF 6.23 M (2839)Favorites

      Abstract:Aim To explore the correlation between atherogenic index of plasma (AIP), triglyceride-glucose (TyG) index and their severity in patients with chronic coronary syndrome (CCS). Methods A total of 298 patients diagnosed with CCS by coronary angiography were retrospectively selected from Cardiology Department of the First Hospital of Lanzhou University, from May 2017 to May 2023. Clinical indexes were collected and Gensini scores were calculated based on the results of the coronary angiography, clinical data of different Gensini integral groups was compared. Linear regression was used to analyze factors that influence the elevation of Gensini scores, and receiver operator characteristic (ROC) curve was used to determine the predictive value of AIP and TyG index for the severity of coronary artery lesions in CCS. Results The research sample consisted mostly of males (77.9%) with a mean age of (61.9±8.0) years. The adjusted AIP (aAIP) and TyG index of high Gensini score group were higher than those of low Gensini score group and medium Gensini score group, and the differences were significant. Linear regression analysis revealed that total cholesterol (TC), high density lipoprotein cholesterol (HDLC), aAIP and TyG index were the factors influencing the elevated Gensini scores (all P<0.05). Correlation analysis revealed that aAIP and TyG index were negatively correlated with left ventricular ejection fraction (LVEF), positively correlated with Gensini scores, and positively correlated with stent implantation and the number of stent implantation (all P<0.05). The ROC curve results indicated that when the aAIP threshold was 1.924, the area under the ROC curve (AUC) for predicting Gensini score ≥41 points was 0.583 (95%CI 0.525~0.640), with a sensitivity of 92.62%, a specificity of 25.50%, and Yoden index of 0.181. When the TyG index threshold was 8.748, the AUC for predicting Gensini score ≥41 points was 0.768 (95%CI 0.716~0.815), with a sensitivity of 77.18%, specificity of 67.11%, and Yoden index of 0.443. Conclusion The aAIP and TyG index were positively correlated with the severity of coronary artery disease in CCS patients. Both elevated levels can predict the severity of coronary lesions in CCS patients, but TyG index showed superior predictive ability compared with aAIP.

    • Association between triglyceride-glucose index and risk of stroke:case-control study

      2023, 31(7):588-593.

      Keywords:triglyceride-glucose index stroke case-control study
      Abstract (268)HTML (0)PDF 3.88 M (587)Favorites

      Abstract:Aim To investigate the association between triglyceride-glucose (TyG) index, a substitute marker of insulin resistance, and the risk of stroke. Methods The data were obtained from the baseline survey of Tianjin region in the Cohort Study on Chronic Disease of Communities Natural Population in Beijing, Tianjin and Hebei in 2017—2018.Data were collected by questionnaire, physical examination and laboratory examination. The case group and control group were matched 1∶1 according to the same gender and age ±2 years. Conditional Logistic regression model was used to analyze the association between TyG index and risk of stroke. Results A total of 536 patients were included in the analysis. The TyG index in the case group was higher than that in the control group (P<0.000 1). Multivariate conditional Logistic regression analysis showed that compared with individuals with TyG index<8.38, the OR(95%CI) for stroke in the 8.38≤TyG index<8.7,8.67≤TyG index<9.10, TyG index≥9.10 were 1.13(0.1,2.10), 1.47(0.8,2.74), 2.24(1.6,4.72). Conclusion TyG index was an independent risk factor for stroke. With the increase of TyG index, the risk of stroke increased gradually.

    • The predictive value of the triglyceride-glucose index for cardiovascular and cerebrovascular outcomes in patients with acute coronary syndrome underwent emergency percutaneous coronary intervention

      2023, 31(8):687-696.

      Keywords:triglyceride-glucose index insulin resistance acute coronary syndrome emergency percutaneous coronary intervention major adverse cardiovascular and cerebrovascular events
      Abstract (503)HTML (0)PDF 5.99 M (1056)Favorites

      Abstract:Aim To investigate the relationship between the triglyceride-glucose (TyG) index and major adverse cardiovascular and cerebrovascular events (MACCE) in the acute coronary syndrome(ACS) patients underwent emergency percutaneous coronary intervention (PCI) with drug-eluting stents. Methods Overall, 2 249 patients with ACS underwent emergency PCI were enrolled in this study. The patients were divided into high TyG index group and low TyG index group according to the median TyG index. The incidence of endpoint events as follows:all-cause death, non-fatal myocardial infarction(MI), non-fatal ischemia stroke, and ischemia-driven revascularization were determined and compared between two groups.Unitivariate and multivariate Cox analysis were used to evaluate the predictive value of the TyG index for MACCE. Subgroup analysis was used to evaluate the consistency of the predictive value of the TyG index for MACCE. Results Overall, 299 (13.3%) endpoint events were documented during a 66-month follow-up. Compared with the low TyG index group, the high TyG index group had a significantly higher incidence of MACCE (17.1% vs. 9.5%, P<0.001), all-cause death (6.2% vs. 3.7%, P=0.007), cardiac death (4.4% vs. 2.1%, P=0.002), non-fatal MI (1.0% vs. 0.3%, P=0.001), non-fatal ischemia stroke (2.0% vs. 1.0%, P=0.039) and ischemia-driven revascularization (7.8% vs. 4.8%, P=0.001). The multivariable Cox regression analysis further revealed that the TyG index was an independent predictor of MACCE (hazard ratio (HR)1.0,5% confidence interval (CI) 1.304~2.242,P<0.001). The results of subgroup analysis showed that the predictive effect of TyG index on MACCE still existed in different subgroups. Conclusion The TyG index might be an independent predictor of MACCE in patients with ACS underwent emergency PCI with drug-eluting stents.

    • Correlation between TyG index and severity of coronary artery disease in patients with acute myocardial infarction

      2023, 31(11):969-974.

      Keywords:triglyceride-glucose index acute myocardial infarction severity of coronary artery disease Gensini score
      Abstract (532)HTML (0)PDF 3.74 M (1047)Favorites

      Abstract:Aim To investigate the correlation between triglyceride-glucose (TyG) index and the severity of coronary artery disease assessed in patients with acute myocardial infarction (AMI). Methods The study restrospectively selected 424 patients with AMI in the Fourth Affiliated Hospital of Xinjiang Medical University from January 2020 to March 2023. Clinical data and results of coronary angiography (CAG) were collected. Gensini score was used to quantitatively assess the degree of coronary artery stenosis. According to tertiles of the Gensini, the patients were classifified into three groups:low Gensini score group (<45 points, n=140), medium Gensini score group (45~86 points, n=143), and high Gensini score group (≥87 points, n=141). The associations between TyG index and the occurrence of coronary artery disease with high Gensini score by Logistic regression analysis; Spearman correlation was used to analyze the correlation between TyG index and Gensini score in AMI patients; ROC curve was used to analyze the value of TyG index in predicting the severity of coronary artery lesions. Results TyG index of high Gensini score group was significantly higher than that of low and medium Gensini score group (P<0.05). Logistic regression analysis showed that TyG index was an independent risk factor for severe coronary lesions in AMI patients (OR=13.7,5%CI:2.642~67.235, P=0.002). Spearman correlation analysis showed that TyG index was positively correlated with the severity of coronary artery disease (r=0.331, P<0.001). ROC curve analysis showed that the area under curve of TyG index was 0.680 (95%CI:0.630~0.731, P<0.001). When the cut-off value of TyG index was 1.555, the predicted efficacy of of severe coronary artery disease in patients with AMI was the highest, with a sensitivity of 79.4% and a specificity of 50.5%. Conclusion TyG, as a novel biomarker, was significantly and independently associated with the severity of the coronary arteries in patients with AMI.

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