Research progress on the mechanism of atherosclerosis caused by triglyceride-rich lipoprotein and its residues

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Research progress on the mechanism of atherosclerosis caused by triglyceride-rich lipoprotein and its residues
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                        LIU Meiyi1LIU Meiyi
Beijing University of Chinese Medicine, Beijing 100029, China
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SHAO Mingyan1SHAO Mingyan
Beijing University of Chinese Medicine, Beijing 100029, China
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GUAN Yuanyuan1GUAN Yuanyuan
Beijing University of Chinese Medicine, Beijing 100029, China
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LI Fangli2LI Fangli
Department of Preventive Medicine, Shenzhen Hospital Longgang, Beijing University of Chinese Medicine, Shenzhen, Guangdong 518000, China
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LI Lingru3LI Lingru
National Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing100029, China
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Affiliation:1.Beijing University of Chinese Medicine, Beijing 100029, China;2.Department of Preventive Medicine, Shenzhen Hospital (Longgang), Beijing University of Chinese Medicine, Shenzhen, Guangdong 518000, China;3.National Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing100029, China)
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Abstract:

Triglyceride (TG) is transported in the blood as specific triglyceride-rich lipoprotein (TRL). When TRL is overproduced or the catabolism is not timely, cholesterol ester-rich residues is formed. Both TRL and its residues contribute to the development of atherosclerosis (As) through various direct and indirect mechanisms. Currently, the combination of lifestyle interventions and Western medicines is considered the preferred treatment strategy for As. However, lipid-lowering therapy alone cannot fully eliminate the residual risk of As. In contrast, traditional Chinese medicine emphasizes the holistic regulation of bodily functions to prevent and treat As. This paper will begin by examining the metabolic mechanisms of TRL, elucidate the role of TRL and its residues in the risk of As occurrence, and summarize current strategies targeting the TRL metabolic pathway to reduce the incidence of As.

Key words:triglyceride; triglyceride-rich lipoprotein; atherosclerosis; medication treatment

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LIU Meiyi, SHAO Mingyan, GUAN Yuanyuan, LI Fangli, LI Lingru. Research progress on the mechanism of atherosclerosis caused by triglyceride-rich lipoprotein and its residues[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2025,33(4):355-362.

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Received:January 03,2024
Revised:May 13,2024
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Online: May 16,2025
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