2025年5月22日 周四
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Atherosclerotic vascular remodeling induced by phenotypic switching of vascular smooth muscle cell
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Department of Neurology, Jinling Hospital Affiliated to Nanjing University Medical School (General Hospital of Eastern Theater Command), Nanjing, Jiangsu 210002, China)

Clc Number:

R5;R363

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    Abstract:

    Atherosclerosis is a chronic vascular disease, whose early manifestations are vascular intimal hyperplasia and plaque formation, and the late vascular events can be caused by plaque rupture after erosion. In the process of atherosclerosis, vascular smooth muscle cell(VSMC) in the arterial media play a key role in vascular remodeling, and their phenotype conversion has an important impact on maintaining vascular homeostasis. Due to methodological limitations, the previous understanding of VSMC function is limited; With the rapid development of lineage tracing and single-cell sequencing technology, the role of VSMC in atherosclerosis has been deeply explored in recent years. This paper summarizes the emerging research methods of VSMC in recent years, and reviews the literature on the roles and mechanisms of phenotypic switching of VSMC in vascular remodeling.

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WANG Jia, PENG Mengna, GAO Jie, XU Gelin. Atherosclerotic vascular remodeling induced by phenotypic switching of vascular smooth muscle cell[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2025,33(3):269-276.

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History
  • Received:January 25,2024
  • Revised:March 09,2024
  • Online: April 02,2025
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