2025年6月28日 周六
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Advances in fat mass and obesity-related protein-mediated N6-adenylate methylation in atherosclerosis
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1.Institute of Translational Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China;2.Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi 541106, China)

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R365；R5

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    Abstract:

    N6-methyladenosine (m6A) is the most common mRNA modification in eukaryotes, and fat mass and obesity-related protein (FTO), are its demethylases, which efficiently remove the modification of m6A mRNA, and is strongly associated with obesity. Atherosclerosis is a chronic inflammatory lesion of the blood vessel wall driven by lipids.It was found that FTO-mediated m6A may influence the process of atherosclerosis through lipid metabolism, oxidative stress, mitochondrial dysfunction, and macrophage foaminess.

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XIE Zhuoyi, CHEN Songtao, SUN Xuan, YANG Peijuan, CHEN Yali, GUI Qinjun, ZUO Jianhong. Advances in fat mass and obesity-related protein-mediated N6-adenylate methylation in atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2025,33(3):257-263.

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History
  • Received:March 15,2024
  • Revised:April 03,2024
  • Online: April 02,2025
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