Advances in fat mass and obesity-related protein-mediated N<sup>6</sup>-adenylate methylation in atherosclerosis

Home > Archive>Volume 33, Issue 3, 2025 >257-263

Advances in fat mass and obesity-related protein-mediated N6-adenylate methylation in atherosclerosis
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                        XIE Zhuoyi1XIE Zhuoyi
Institute of Translational Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China
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CHEN Songtao2CHEN Songtao
Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi 541106, China
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SUN Xuan1SUN Xuan
Institute of Translational Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China
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YANG Peijuan1YANG Peijuan
Institute of Translational Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China
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CHEN Yali1CHEN Yali
Institute of Translational Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China
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GUI Qinjun1GUI Qinjun
Institute of Translational Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China
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ZUO Jianhong1ZUO Jianhong
Institute of Translational Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China
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Affiliation:1.Institute of Translational Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China;2.Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi 541106, China)
Clc Number:R365；R5
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Abstract:

N⁶-methyladenosine (m⁶A) is the most common mRNA modification in eukaryotes, and fat mass and obesity-related protein (FTO), are its demethylases, which efficiently remove the modification of m⁶A mRNA, and is strongly associated with obesity. Atherosclerosis is a chronic inflammatory lesion of the blood vessel wall driven by lipids.It was found that FTO-mediated m⁶A may influence the process of atherosclerosis through lipid metabolism, oxidative stress, mitochondrial dysfunction, and macrophage foaminess.

Key words:fat mass and obesity-related protein; N⁶-methyladenosine; atherosclerosis

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XIE Zhuoyi, CHEN Songtao, SUN Xuan, YANG Peijuan, CHEN Yali, GUI Qinjun, ZUO Jianhong. Advances in fat mass and obesity-related protein-mediated N⁶-adenylate methylation in atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2025,33(3):257-263.

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Received:March 15,2024
Revised:April 03,2024
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Online: April 02,2025
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