The key role of liquid-liquid phase separation in atherosclerosis

Home > Archive>Volume 33, Issue 3, 2025 >185-193, 201

The key role of liquid-liquid phase separation in atherosclerosis
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                        ZHAO Fangyao1,2ZHAO Fangyao
Experiment Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China;School of Life Sciences, China Jiliang University, Hangzhou, Zhejiang 310018, China
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LI Junhao2LI Junhao
School of Life Sciences, China Jiliang University, Hangzhou, Zhejiang 310018, China
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YANG Ke1,2YANG Ke
Experiment Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China;School of Life Sciences, China Jiliang University, Hangzhou, Zhejiang 310018, China
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YANG Hongjun1YANG Hongjun
Experiment Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China
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Affiliation:1.Experiment Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China;2.School of Life Sciences, China Jiliang University, Hangzhou, Zhejiang 310018, China)
Clc Number:R5
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Abstract:

Liquid-liquid phase separation is an important process in which intracellular biomolecules condense to form membraneless organelles, playing a significant role in cell signaling and gene expression regulation. Studies have shown that liquid-liquid phase separation may be involved in the occurrence and development of atherosclerosis and has potential applications in the diagnosis and treatment of the disease. This article introduces the concept and mechanism of liquid-liquid phase separation, delves into the relationship between liquid-liquid phase separation and atherosclerosis, summarizes the progress of liquid-liquid phase separation in atherosclerosis research, and looks forward to its application prospects.

Key words:liquid-liquid phase separation; atherosclerosis; research progress; application prospect

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ZHAO Fangyao, LI Junhao, YANG Ke, YANG Hongjun. The key role of liquid-liquid phase separation in atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2025,33(3):185-193, 201.

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Received:October 15,2024
Revised:December 07,2024
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Online: April 02,2025
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