Advance in biomechanical factors regulating angiogenesis in atherosclerotic plaques

doi:10. 20039/ j. cnki. 1007-3949. 2025. 02. 002

Home > Archive>Volume 33, Issue 2, 2025 >102-107. DOI:10. 20039/ j. cnki. 1007-3949. 2025. 02. 002

Advance in biomechanical factors regulating angiogenesis in atherosclerotic plaques
DOI:
                        10. 20039/ j. cnki. 1007-3949. 2025. 02. 002
                    
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                        PENG Chengxiu1PENG Chengxiu
Biomedical Engineering Research Laboratory,West China School of Basic Medicine and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China
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CHEN Hanxiao1CHEN Hanxiao
Biomedical Engineering Research Laboratory,West China School of Basic Medicine and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China
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ZENG Yuhan2ZENG Yuhan
School of Chemical Engineering, Sichuan University, Chengdu, Sichuan 610065, China
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FENG Yujing1FENG Yujing
Biomedical Engineering Research Laboratory,West China School of Basic Medicine and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China
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LI Yuhao1LI Yuhao
Biomedical Engineering Research Laboratory,West China School of Basic Medicine and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China
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SHEN Yang1SHEN Yang
Biomedical Engineering Research Laboratory,West China School of Basic Medicine and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China
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Affiliation:1.Biomedical Engineering Research Laboratory,West China School of Basic Medicine and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China;2.School of Chemical Engineering, Sichuan University, Chengdu, Sichuan 610065, China)
Clc Number:R5；R363
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Abstract:

Angiogenesis within atherosclerotic plaques is a critical determinant of plaque stability. The biomechanical microenvironment, consisting of fluid shear force, plaque structural stress, and matrix stiffness, serves as significant factors in mediating plaque angiogenesis. Endothelial cells respond to mechanical signals and participate in plaques neovascularization through force chemical signal transduction mechanisms. This review provides an overview of the mechanisms by which mechanical factors regulate angiogenesis within plaques and offers a novel therapeutic approach for the prevention and treatment of atherosclerosis.

Key words:atherosclerosis plaque; angiogenesis; mechanical microenvironment

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PENG Chengxiu, CHEN Hanxiao, ZENG Yuhan, FENG Yujing, LI Yuhao, SHEN Yang. Advance in biomechanical factors regulating angiogenesis in atherosclerotic plaques[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2025,33(2):102-107.

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Received:April 09,2024
Revised:June 04,2024
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Online: March 05,2025
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