Aim To explore the effect of age on myocardial remodeling after percutaneous coronary intervention (PCI) in patients with acute anterior myocardial infarction. Methods This study was a cross-sectional study analyzing clinical data of regular follow-up at 1,3, 6 and 12 months after PCI for acute anterior myocardial infarction. According to the age of the patients, they were divided into a low age group (＜65 years old) and a high age group (≥65 years old). The differences in baseline data, biochemical indexes, coronary angiography, inflammatory factor levels, and cardiac ultrasound indexes between the two groups were analyzed, and the correlation analysis between age and inflammatory factors and the multivariate linear regression analysis of diastolic function were performed. Results A total of 87 patients with acute anterior myocardial infarction were selected, aged (62±13) years, including 67 males (77.0%), 43 in the low age group and 44 in the high age group. Compared with the low age group, the levels of inflammatory factors such as C-reactive protein, interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) increased in the high age group, while ultrasound indicators such as mitral valve annulus septal e′, mitral valve flow velocity E/A, and mitral valve annulus sidewall e′ decreased (P＜0.05). Older age was an independent risk factor for a decrease in mitral valve flow velocity E/A, mitral valve annulus sidewall e′ and mitral valve annulus septal e′ in patients with acute anterior myocardial infarction 6 months after PCI (P＜0.05). Conclusion Age is an independent risk factor for reduced diastolic function after PCI in acute anterior myocardial infarction, inflammatory factor such as IL-1β, IL-6 and TNF-α may play a role in the impaired diastolic function after PCI in age-related acute anterior myocardial infarction.