Endogenous bioactive small molecules and vascular calcification

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Endogenous bioactive small molecules and vascular calcification
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                        WANG Rui1,2,3WANG Rui
Laboratory of Cardiovascular Bioactive Molecule, School of Basic Medical Sciences, Peking University,Beijing 100083, China;State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University,Beijing 100083, China;Department of Pathogen Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100083, China
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CHAI Sanbao4CHAI Sanbao
Department of Endocrinology and Metabolism, Peking University International Hospital, Beijing 102206, China
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QI Yongfen1,2,3QI Yongfen
Laboratory of Cardiovascular Bioactive Molecule, School of Basic Medical Sciences, Peking University,Beijing 100083, China;State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University,Beijing 100083, China;Department of Pathogen Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100083, China
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Affiliation:1.Laboratory of Cardiovascular Bioactive Molecule, School of Basic Medical Sciences, Peking University,Beijing 100083, China;2.State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University,Beijing 100083, China;3.Department of Pathogen Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100083, China;4.Department of Endocrinology and Metabolism, Peking University International Hospital, Beijing 102206, China)
Clc Number:R363.1;R5
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Abstract:

Endogenous bioactive small molecules are characterized by low molecular weight, high biological activity, low immunogenicity, and rapid synthesis and metabolism, play a pivotal role in maintaining vascular homeostasis.Vascular calcification (VC) is a abnormal deposition of calcium and phosphorus in the vessel wall. Endogenous bioactive small molecules such as cardiovascular bioactive peptides, adipokines and gaseous molecules participate in the process of VC through various mechanisms. This review summarises the advances in relationship between endogenous bioactive small molecules and the occurrence, development, and related mechanisms of VC.

Key words:vascular calcification; endogenous bioactive small molecule; cardiovascular bioactive peptide; adipokine; gaseous molecule

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WANG Rui, CHAI Sanbao, QI Yongfen. Endogenous bioactive small molecules and vascular calcification[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2025,33(1):1-8.

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Received:March 29,2024
Revised:June 04,2024
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Online: January 26,2025
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