As a new clinical trial mode, decentralized & digitalized clinical trial (DCT) is based on digital health equipment and uses internet and artificial intelligence technologies to complete the screening, registration, randomization, intervention, evaluation and follow-up of subjects, which is helpful to improve efficiency and reduce trial costs. The DCT mode has been applied to evaluate the treatment and management effects of cardiovascular diseases such as atrial fibrillation, heart failure, coronary heart disease, and hypertension, showing broad development prospects and application space. This article will provide a brief introduction to representative DCT in the global cardiovascular disease field, and look forward to the application prospects of this model, providing reference and guidance for accelerating the development of cardiovascular DCT in China.