The role of Traditional Chinese Medicine in regulating vitamin D in panvascular diseases based on kidney storing essence
Author:
Affiliation:

1.Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550025, China;2.Dejiang Nation Hospital of Traditional Chinese Medicine, Tongren, Guizhou 565200, China;3.The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550002, China)

Clc Number:

R5

  • Article
  • | |
  • Metrics
  • |
  • Reference [56]
  • | |
  • Cited by
  • | |
  • Comments
    Abstract:

    Atherosclerosis (As) is a chronic inflammatory disease caused by lipid deposition. Panvascular diseases, which are mainly caused by As, have gradually attracted the attention of many scholars, and their main pathological features are vascular lesions. Vitamin D plays an important role in anti-As in panvascular diseases. It is involved in the regulation of renin-angiotensin system (RAS), endothelial cell injury, immune response, neutrophil extracellular traps (NET) regulation, apoptosis and autophagy, and is a new target in panvascular diseases research. Traditional Chinese Medicine (TCM) has certain advantages in the prevention and treatment of panvascular diseases. Among them, single herbs, active ingredients and compound prescriptions can regulate vitamin D-related metabolism, and have unique scientific value for the prevention and treatment of As. This article mainly discusses the role of vitamin D in multiple pathological links of panvascular diseases and related Chinese medicine interventions, aiming to provide effective ideas for the prevention and treatment of panvascular diseases from the perspective of vitamin D.

    Reference
    [1] 葛均波.深化系统生物学理念, 推进泛血管医学学科发展.中华心血管病杂志, 6,4(5):373-374.GE J B.Deepening the concept of systems biology and promoting the development of panvascular medicine discipline.Chin J Cardiol, 6,4(5):373-374.
    [2] 杨靖, 王克强, 霍勇, 等.泛血管疾病综合防治科学声明.中国循环杂志, 9,4(11):1041-1046.YANG J, WANG K Q, HUO Y, et al.Scientifc statement for the prevention and treatment of panvascular disease.Chin Circ J, 9,4(11):1041-1046.
    [3] PERROTTA P, EMINI VESELI B, VAN DER VEKEN B, et al.Pharmacological strategies to inhibit intra-plaque angiogenesis in atherosclerosis.Vascul Pharmacol, 9,2:72-78.
    [4] LIBBY P, HANSSON G K.From focal lipid storage to systemic inflammation:JACC review topic of the week.J Am Coll Cardiol, 9,4(12):1594-1607.
    [5] 尤良震, 赵晨, 张晓雨, 等.病络理论下泛血管疾病中西医结合防治理论基础及实施思路.中国中西医结合杂志, 2,2(11):1392-1395.YOU L Z, ZHAO C, ZHANG X Y, et al.Theoretical basis and implementation of integrated traditional Chinese and Western medicine for prevention and treatment of panvascular diseases under abnormal collateral.Chin J Integr Tradit West Med, 2,2(11):1392-1395.
    [6] 夏维波, 章振林, 林华, 等.维生素D及其类似物临床应用共识.中华骨质疏松和骨矿盐疾病杂志, 8,1(1):1-19.XIA W B, ZHANG Z L, LIN H, et al.Consensus on the clinical application of vitamin D and its analogues.Chin J Osteoporos Bone Miner Res, 8,1(1):1-19.
    [7] 陈云志, 管连城, 高洁, 等.维生素D轴:中医补肾方药的潜在靶点.时珍国医国药, 7,8(9):2210-2212.CHEN Y Z, GUAN L C, GAO J, et al.Vitamin D axis:potential targets of traditional Chinese medicine kidney tonifying formulas.Lishizhen Med Mater Med Res, 7,8(9):2210-2212.
    [8] CHENG J B, LEVINE M A, BELL N H, et al.Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase.Proc Natl Acad Sci U S A, 4,1(20):7711-7715.
    [9] CASHMAN K D, VAN DEN HEUVEL E G, SCHOEMAKER R J, et al.25-Hydroxy vitamin D as a biomarker of vitamin D status and its modeling to inform strategies for prevention of vitamin D deficiency within the population.Adv Nutr, 7,8(6):947-957.
    [10] PILZ S, VERHEYEN N, GRBLER M R, et al.Vitamin D and cardiovascular disease prevention.Nat Rev Cardiol, 6,3(7):404-417.
    [11] WENG S, SPRAGUE J E, OH J, et al.Vitamin D deficiency induces high blood pressure and accelerates atherosclerosis in mice.PLoS One, 3,8(1):e54625.
    [12] 肖素军, 赵明.动脉粥样硬化与免疫.中国动脉硬化杂志, 2,0(4):277-286.XIAO S J, ZHAO M.Atherosclerosis and immunity.Chin J Arterioscler, 2,0(4):277-286.
    [13] SCRAGG R, STEWART A W, WAAYER D, et al.Effect of monthly high-dose vitamin D supplementation on cardiovascular disease in the vitamin D assessment study :a randomized clinical trial.JAMA Cardiol, 7,2(6):608-616.
    [14] 乔莞宁, 陈虹印, 张扬.氧化应激与动脉粥样硬化.中国动脉硬化杂志, 3,1(4):312-321.QIAO G N, CHEN H Y, ZHANG Y.Oxidative stress and atherosclerosis.Chin J Arterioscler, 3,1(4):312-321.
    [15] BIMA A I, MAHDI A S, AL FAYEZ F F, et al.Cellular senescence and vitamin D deficiency play a role in the pathogenesis of obesity-associated subclinical atherosclerosis:study of the potential protective role of vitamin D supplementation.Cells, 1,0(4):920.
    [16] 林丽明, 张美金, 许昌声, 等.维生素D通过抑制Pin1介导线粒体氧化应激拮抗高糖诱导的人脐静脉内皮细胞凋亡.中国病理生理杂志, 8,4(1):15-21.LIN L M, ZHANG M J, XU C S, et al.Vitamin D prevents high glucose-induced human umbilical vein endothelial cell apoptosis by inhibition of prolyl isomerase 1-mediated mitochondrial oxidative stress.Chin J Pathophysiol, 8,4(1):15-21.
    [17] TAKEDA M, YAMASHITA T, SASAKI N, et al.Oral administration of an active form of vitamin D3 (calcitriol) decreases atherosclerosis in mice by inducing regulatory T cells and immature dendritic cells with tolerogenic functions.Arterioscler Thromb Vasc Biol, 0,0(12):2495-2503.
    [18] BIVONA G, AGNELLO L, CIACCIO M, et al.The immunological implication of the new vitamin D metabolism.Cent Eur J Immunol, 8,3(3):331-334.
    [19] BASYREVA L Y, VAKHRUSHEVA T V, LETKEMAN Z V, et al.Effect of vitamin D3 in combination with omega-3 polyunsaturated fatty acids on NETosis in type 2 diabetes mellitus patients.Oxid Med Cell Longev, 1,1:8089696.
    [20] HANDONO K, SIDARTA Y O, PRADANA B A, et al.Vitamin D prevents endothelial damage induced by increased neutrophil extracellular traps formation in patients with systemic lupus erythematosus.Acta Med Indones, 4,6(3):189-198.
    [21] LU R, ZHANG Y G, XIA Y, et al.Imbalance of autophagy and apoptosis in intestinal epithelium lacking the vitamin D receptor.FASEB J, 9,3(11):11845-11856.
    [22] FANG M, ZHONG C.Vitamin D receptor regulates autophagy to inhibit apoptosis and promote proliferation in hepatocyte injury.J Nippon Med Sch, 3,0(1):89-95.
    [23] LE T Y L, OGAWA M, KIZANA E, et al.Vitamin D improves cardiac function after myocardial infarction through modulation of resident cardiac progenitor cells.Heart Lung Circ, 8,7(8):967-975.
    [24] CHEN F H, LIU T, XU L, et al.Association of serum vitamin D level and carotid atherosclerosis:a systematic review and Meta-analysis.J Ultrasound Med, 8,7(6):1293-1303.
    [25] FERRAREZI D A, BELLILI-MUOZ N, DUBOIS-LAFORGUE D, et al.Allelic variations of the vitamin D receptor (VDR) gene are associated with increased risk of coronary artery disease in type 2 diabetics:the DIABHYCAR prospective study.Diabetes Metab, 3,9(3):263-270.
    [26] 陶蕾, 纪立伟, 王艳春.他汀类药物对动脉粥样硬化的疗效研究.中国现代医学杂志, 7,7(14):93-98.TAO L, JI L W, WANG Y C.Effect of statins on atherosclerosis.Chin J Mod Med, 7,7(14):93-98.
    [27] 陈琼, 黄水清.黄芪总皂苷、当归挥发油对动脉粥样硬化ApoE-/-小鼠脂质代谢的影响.中药新药与临床药理, 1,2(6):791-798.CHEN Q, HUANG S Q.Effect of Astragalus saponins and angelica volatile oil on lipid metabolism in atherosclerotic ApoE-/- mice.Traditional Chin Drug Res Clin Pharmacol, 1,2(6):791-798.
    [28] 秦合伟, 张勤生, 李彦杰, 等.黄芪甲苷调控miR-17-5p与PCSK9/VLDLR信号通路抗动脉粥样硬化的分子机制研究.中国中药杂志, 2,7(2):492-498.QIN H W, ZHANG Q S, LI Y J, et al.Molecular mechanism of astragaloside Ⅳ against atherosclerosis by regulating miR-17-5p and PCSK9/VLDLR signal pathway.China J Chin Mater Med, 2,7(2):492-498.
    [29] 葛凡, 王文恺, 朱景天, 等.黄芪甲苷通过NLPR3炎性小体调节糖尿病动脉粥样硬化早期大鼠血脂及炎症因子的研究.南京中医药大学学报, 1,7(3):383-387.GE F, WANG W K, ZHU J T, et al.Astragaloside Ⅳ regulates blood lipid and inflammatory factors through NLPR3 inflammasome in early diabetic atherosclerosis rats.J Nanjing Univ Tradit Chin Med, 1,7(3):383-387.
    [30] 巩莎, 可海霞.黄芪甲苷通过抑制氯化物细胞内通道蛋白4/ADP核糖基化因子6信号通路改善血管紧张素Ⅱ诱导的高血压大鼠模型的心肌损伤.中华高血压杂志, 4,2(1):43-50.GONG S, KE H X.Astragaloside Ⅳ ameliorates myocardial injury in angiotensin Ⅱ induced hypertension rat model by regulating chloride intracellular channel protein 4/ADP-ribosylation factor 6 signal pathway.Chin J Hypertens, 4,2(1):43-50.
    [31] LI X, ZHOU J, DOU Y, et al.The protective effects of angelica organic acid against ox-LDL-induced autophagy dysfunction of HUVECs.BMC Complement Med Ther, 0,0(1):164.
    [32] ZHAO W, MA G, CHEN X.Lipopolysaccharide induced LOX-1 expression via TLR4/MyD88/ROS activated p38MAPK-NF-kappa B pathway.Vascul Pharmacol, 4,3(3):162-172.
    [33] BARIK P, SHIBU M A, HSIEH D J, et al.Cardioprotective effects of transplanted adipose-derived stem cells under AngⅡ stress with Danggui administration augments cardiac function through upregulation of insulin-like growth factor 1 receptor in late-stage hypertension rats.Environ Toxicol, 1,6(7):1466-1475.
    [34] 李藤藤, 徐东升, 李琪, 等.淫羊藿苷对ox-LDL诱导的RAW264.7细胞凋亡及炎症的影响.中国比较医学杂志, 2,2(3):9-15.LI T T, XU D S, LI Q, et al.Effect of icariin the apoptosis and inflammation of RAW264.7 cells induced by ox-LDL.Chin J Comp Med, 2,2(3):9-15.
    [35] QIAN Z, ZHU L, LI Y, et al.Icarrin prevents cardiomyocyte apoptosis in spontaneously hypertensive rats by inhibiting endoplasmic reticulum stress pathways.J Pharm Pharmacol, 1,3(8):1023-1032.
    [36] KIM J Y, SHIM S H.Epimedium koreanum extract and its flavonoids reduced atherosclerotic risk via suppressing modification of human HDL.Nutrients, 9,1(5):1110.
    [37] ZHANG K, LU J, MORI T, et al.Baicalin increases VEGF expression and angiogenesis by activating the ERR{alpha}/PGC-1{alpha} pathway.Cardiovasc Res, 1,9(2):426-435.
    [38] 刘明超.穿心莲对动脉粥样硬化的影响及其机制的研究.济南:山东中医药大学, 2021.LIU M C.The effect and mechanism of andrographis paniculata on atherosclerosis.Ji'nan:Shandong University of Traditional Chinese Medicine, 2021.
    [39] 赵艺涵.中药治疗颈动脉粥样硬化的配伍规律及川芎嗪稳定斑块的研究.北京:北京中医药大学, 2021.ZHAO Y H.Study on the compatibility of traditional Chinese medicine in the treatment of carotid atherosclerosis and the stable plaque of ligustrazine.Beijing:Beijing University of Chinese Medicine, 2021.
    [40] LIU H, ZHU L, CHEN L, et al.Therapeutic potential of traditional Chinese medicine in atherosclerosis:a review.Phytother Res, 2,6(11):4080-4100.
    [41] 宋珂.四妙勇安汤通过激活PPARγ调控相关炎症通路对ApoE-/- 小鼠AS肝损伤的影响.北京:北京中医药大学, 2019.SONG K.Simiao Yongan Tang activates PPARγ and the effect of regulating related inflammatory pathways on ApoE-/- mouse AS liver injury.Beijing:Beijing University of Chinese Medicine, 2019.
    [42] 漆仲文, 李萌, 朱科, 等.四妙勇安汤对动脉粥样硬化小鼠动脉血管斑块外膜滋养血管通透性的影响.中国实验方剂学杂志, 9,5(11):24-28.QI Z W, LI M, ZHU K, et al.Effect of Simiao Yongan Tang on permeability of vasa vasorum of atherosclerotic plaque.Chin J Exp Tradit Med Form, 9,5(11):24-28.
    [43] 李琳.四妙勇安汤抗糖尿病心肌病的效应成分及分子机制研究.北京:北京中医药大学, 2021.LI L.Study on the effective components and molecular mechanism of Simiao Yongan decoction against diabetes cardiomyopathy.Beijing:Beijing University of Chinese Medicine, 2021.
    [44] 李秋芳, 王文恺, 龚曼, 等.当归补血汤及其活性成分通过NLRP3/ASC/Caspase-1通路调控糖尿病大鼠动脉粥样硬化及网络药理学研究.中成药, 2,4(6):1987-1992.LI Q F, WANG W K, GONG M, et al.Danggui Buxue decoction and its active ingredients regulate atherosclerosis and network pharmacology in diabetes rats through NLRP3/ASC/Caspase-1 pathway.Chin Tradit Pat Med, 2,4(6):1987-1992.
    [45] 许二巾.当归补血汤抗ApoE基因敲除小鼠动脉粥样硬化的作用及机制的研究.广州:广州中医药大学, 2019.XU E J.The study on the protective effect of Danggui Buxue Tang in ApoE knockout mice atherosclerosis and its mechanism.Guangzhou:Guangzhou University of Chinese Medicine, 2019.
    [46] 王红松, 单晓晓, 赵国栋, 等.半夏白术天麻汤对ApoE-/-小鼠动脉粥样硬化的干预作用及其机制.中国实验方剂学杂志, 1,7(7):9-15.WANG H S, SHAN X X, ZHAO G D, et al.Effect and mechanism of Banxia Baizhu Tianmatang on atherosclerosis in ApoE-/- mice.Chin J Exp Tradit Med Form, 1,7(7):9-15.
    [47] XIANG Y, ZHENG F, ZHANG Q, et al.Tanreqing injection regulates cell function of hypoxia-induced human pulmonary artery smooth muscle cells (HPASMCs) through TRPC1/CX3CL1 signaling pathway.Oxid Med Cell Longev, 2,2:3235102.
    [48] JIANG Y H, ZHANG P, TAO Y, et al.Banxia Baizhu Tianma decoction attenuates obesity-related hypertension.J Ethnopharmacol, 1,6:113453.
    [49] 陈云志, 秦忠, 王瑶瑶, 等.试论维生素D为“肾藏精”理论的物质基础.环球中医药, 0,3(6):447-448.CHEN Y Z, QIN Z, WANG Y Y, et al.On the material basis of vitamin D as the theory of “kidney storing essence”.Glob Tradit Chin Med, 0,3(6):447-448.
    [50] 管连城, 陈功, 高洁, 等.淫羊藿苷对维生素D缺乏大鼠肾上腺皮质CYP17A1mRNA表达及皮质醇的影响.时珍国医国药, 7,8(3):520-521.GUAN L C, CHEN G, GAO J, et al.The effect of icariin on the expression of CYP17A1 mRNA and cortisol in the adrenal cortex of vitamin D deficient rats.Lishizhen Med Mater Med Res, 7,8(3):520-521.
    [51] 陈伟, 王焕珍, 柴艺汇, 等.淫羊藿苷对异丙肾上腺素诱导H9C2细胞心肌重塑模型CYP27B, 维生素D受体mRNA表达的影响.时珍国医国药, 6,7(11):2568-2570.CHEN W, WANG H Z, CHAI Y H, et al.The effect of icariin on the mRNA expression of CYP27B and vitamin D receptors in isoproterenol induced myocardial remodeling model of H9C2 cells.Lishizhen Med Mater Med Res, 6,7(11):2568-2570.
    [52] 柴艺汇, 高洁, 陈功, 等.淫羊藿苷对异丙肾上腺素诱导的肥大HL-1心肌细胞维生素D受体mRNA表达的影响.时珍国医国药, 7,8(7):1587-1589.CHAI Y H, GAO J, CHEN G, et al.The effect of icariin on the mRNA expression of vitamin D receptor induced by isoproterenol in hypertrophic HL-1 cardiomyocytes.Lishizhen Med Mater Med Res, 7,8(7):1587-1589.
    [53] 李文, 张孟之, 陈云志, 等.当归补血汤对维甲酸诱导的骨质疏松大鼠肾脏VDR、CYP27B1的影响.时珍国医国药, 1,2(5):1025-1028.LI W, ZHANG M Z, CHEN Y Z, et al.Effect of Danggui Buxue decoction on VDR and CYP27B1 in kidney of rats osteoporosis model induced by retinoic acid.Lishizhen Med Mater Med Res, 1,2(5):1025-1028.
    [54] 张孟之, 管连城, 秦忠, 等.当归补血汤对维甲酸致骨质疏松模型大鼠卵巢CYP24A1和ERα表达的影响.中药新药与临床药理, 0,1(5):502-507.ZHANG M Z, GUAN L C, QIN Z, et al.Effect of Danggui Buxue decoction on the expression of CYP24A1 and ERα in ovaries of osteoporosis rats induced by retinoic acid.Tradit Chin Drug Res Clin Pharmacol, 0,1(5):502-507.
    [55] 吴雍真, 李倩, 管连城, 等.黄芪多糖调节维生素D/p38MAPK/ERK信号通路改善庆大霉素致肾小管上皮细胞损伤的机制.时珍国医国药, 1,2(10):2312-2315.WU Y Z, LI Q, GUAN L C, et al.The mechanism of astragalus polysaccharide regulating vitamin D/p38MAPK/ERK signaling pathway ameliorate gentamicin induced renal tubular epithelial cell injury.Lishizhen Med Mater Med Res, 1,2(10):2312-2315.
    [56] 陈云志, 杨长福, 郭军, 等.康心汤对异丙肾上腺素诱导实验性心肌肥厚大鼠维生素D代谢的调节作用.中国实验方剂学杂志, 2,8(19):257-260.CHEN Y Z, YANG C F, GUO J, et al.Effect of Kangxin decoction on regulating vitamin D in rats with myocardial hypertrophy induced by isoproterenol.Chin J Exp Tradit Med Form, 2,8(19):257-260.
    Related
    Cited by
    Comments
    Comments
    分享到微博
    Submit
Get Citation

LI Qian, CHAI Yihui, LI Wen, GAO Jie, QIN Zhong, WANG Huanzhen, GUAN Liancheng, CHEN Yunzhi. The role of Traditional Chinese Medicine in regulating vitamin D in panvascular diseases based on kidney storing essence[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2024,32(8):728-736.

Copy
Share
Article Metrics
  • Abstract:115
  • PDF: 4777
  • HTML: 0
  • Cited by: 0
History
  • Received:January 08,2024
  • Revised:March 08,2024
  • Online: August 21,2024
Article QR Code