Progress of bilirubin in the mechanism of atherosclerosis

Home > Archive>Volume 32, Issue 8, 2024 >712-718

Progress of bilirubin in the mechanism of atherosclerosis
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                        GONG Weilei1GONG Weilei
School of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China
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WANG Lei1WANG Lei
School of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China
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YU Yang2YU Yang
School of Laboratory Animal & Shandong Laboratory Animal Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China
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LIU Peiqing1,3LIU Peiqing
School of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China;School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong 510006, China
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Affiliation:1.School of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong 250117, China;2.School of Laboratory Animal & Shandong Laboratory Animal Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong 250117, China;3.School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong 510006, China)
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Abstract:

Atherosclerosis is a chronic vascular wall disease and the most common pathological change in cardiovascular disease. Its pathogenesis is closely related to inflammation, oxidative stress, and lipid deposition. Bilirubin itself has biological activities such as antioxidant and anti-inflammatory effects, and has a protective effect on the cardiovascular system. This article summarizes the mechanism of bilirubin in the development of atherosclerosis and its research progress.

Key words:bilirubin; atherosclerosis; oxidative stress; inflammation; lipid deposition

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GONG Weilei, WANG Lei, YU Yang, LIU Peiqing. Progress of bilirubin in the mechanism of atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2024,32(8):712-718.

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Received:December 14,2023
Revised:March 23,2024
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Online: August 21,2024
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