Research progress of TLR4 in acute myocardial infarction and its treatment

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Research progress of TLR4 in acute myocardial infarction and its treatment
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                        HU Chuting1,2HU Chuting
Department of Laboratory Medicine, Wuhan, Hubei 430022, China;Research Center of Tissue Engineering and Regenerative Medicine, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China
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SONG Yu2SONG Yu
Research Center of Tissue Engineering and Regenerative Medicine, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China
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WANG Lin1,2WANG Lin
Department of Laboratory Medicine, Wuhan, Hubei 430022, China;Research Center of Tissue Engineering and Regenerative Medicine, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China
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Affiliation:1.Department of Laboratory Medicine, Wuhan, Hubei 430022, China;2.Research Center of Tissue Engineering and Regenerative Medicine, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China)
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Abstract:

Acute myocardial infarction (AMI) is a severe disease caused by the persistent coronary artery obstruction, posing a great threat to people's health. In recent years, Toll-like receptor 4 (TLR4), an important pattern recognition receptor, has been widely studied and found to play a crucial role in AMI. This review introduces the recent progress of TLR4 in regulating the progression and prognosis of AMI, and summarizes recent TLR4-targeted therapies using clinical drugs, TLR4 inhibitors, mesenchymal stem cells, and natural bioactive molecules, providing valuable insights for addressing myocardial damage caused by AMI and improving prognosis.

Key words:acute myocardial infarction; Toll-like receptor 4; inflammation

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HU Chuting, SONG Yu, WANG Lin. Research progress of TLR4 in acute myocardial infarction and its treatment[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2024,32(8):705-711.

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Received:January 24,2024
Revised:February 04,2024
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Online: August 21,2024
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