Advances in molecular mechanisms of thoracic aorta disease in Marfan syndrome

Home > Archive>Volume 32, Issue 8, 2024 >645-653

Advances in molecular mechanisms of thoracic aorta disease in Marfan syndrome
DOI:
                        
                    
CSTR:
                        
                    
Author:
                        GAO Qiuyue1,2GAO Qiuyue
Department of Physiology and Pathophysiology, School of Basic Medicine, Capital Medical University, Beijing 100069, China;The Key Laboratory of Cardiovascular Remodeling-related Diseases, Ministry of Education & Beijing Key Laboratory of Metabolic Disorder Related Cardiovascular Disease, Beijing 100069, China
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
ZHAO Yiming1,2ZHAO Yiming
Department of Physiology and Pathophysiology, School of Basic Medicine, Capital Medical University, Beijing 100069, China;The Key Laboratory of Cardiovascular Remodeling-related Diseases, Ministry of Education & Beijing Key Laboratory of Metabolic Disorder Related Cardiovascular Disease, Beijing 100069, China
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
YU Baoqi1,2YU Baoqi
Department of Physiology and Pathophysiology, School of Basic Medicine, Capital Medical University, Beijing 100069, China;The Key Laboratory of Cardiovascular Remodeling-related Diseases, Ministry of Education & Beijing Key Laboratory of Metabolic Disorder Related Cardiovascular Disease, Beijing 100069, China
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site

                    
Affiliation:1.Department of Physiology and Pathophysiology, School of Basic Medicine, Capital Medical University, Beijing 100069, China;2.The Key Laboratory of Cardiovascular Remodeling-related Diseases, Ministry of Education & Beijing Key Laboratory of Metabolic Disorder Related Cardiovascular Disease, Beijing 100069, China)
Clc Number:R543
Fund Project:

Article

Figures

Metrics

Reference

Cited by

Materials

Comments

Abstract:

Aortic aneurysm/dissection is the primary cause of mortality in patients with Marfan syndrome (MFS).Though aberrant activation of the transforming growth factor-β(TGF-β) pathway has been considered the central pathogenic mechanism for MFS aortic aneurysms, recent research has gradually revealed the involvement of other signaling pathways in MFS. This review summarizes the latest researches on the molecular mechanisms of MFS, including classical TGF-β and related signaling pathways such as Notch and nitric oxide(NO), as well as epigenetics and gene therapy, which provide new insights for the prevention and treatment of MFS.

Key words:Marfan syndrome; thoracic aortic aneurysm; thoracic aortic dissection; transforming growth factor-β; matrix metalloproteinase

Get Citation

GAO Qiuyue, ZHAO Yiming, YU Baoqi. Advances in molecular mechanisms of thoracic aorta disease in Marfan syndrome[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2024,32(8):645-653.

Copy

Article Metrics

Abstract:
PDF:
HTML:
Cited by:

History

Received:April 04,2024
Revised:May 21,2024
Adopted:
Online: August 21,2024
Published:

Policies & Instructions

Get Citation

Share

Article Metrics

History

Article QR Code