2025年5月24日 周六
Home > Archive>Volume 32, Issue 6, 2024 >532-538. DOI:10.20039/j.cnki.10073949.2024.06.011.
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The role of dipeptidyl peptidase 4 and its physiological substrate in myocardial ischemia/reperfusion injury
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Affiliation:

1.Translational Medicine Research Center, Guizhou Medical University, Guiyang, Guizhou 550025, China;2.Department of Cardiac Surgery, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550001, China;3.Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University,Guizhou 550025, China;4.School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou 550025, China)

Clc Number:

R5；R363

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    Abstract:

    Myocardial ischemia/reperfusion injury (MIRI) occurs after cardiopulmonary bypass open heart surgery, cardiovascular intervention and thrombolytic therapy, which is the most important cause of cardiac insufficiency, heart failure, and even death in patients after treatment. In recent years, studies have found that the release of endogenous active peptides can alleviate the production of MIRI, and regulating the function and action of endogenous peptides may be one of the most effective ways to treat MIRI. Dipeptidyl peptidase 4 (DPP4) is an important serine protease in mammals, with enzymatic activity to hydrolyze endogenous peptides. Its primary physiological function is to metabolize short peptides, including growth factors, hormones, etc. This review aims to better understand and search for effective therapeutic targets by elucidating the impact of DPP4 on the hydrolysis of endogenous peptides in MIRI, and ultimately provide new ideas for the therapeutic effects of MIRI.

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WANG Lingwei, LEI Jianghui, ZHU Yadi, YANG Siyuan, QIAN Xingkai. The role of dipeptidyl peptidase 4 and its physiological substrate in myocardial ischemia/reperfusion injury[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2024,32(6):532-538.

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History
  • Received:December 27,2023
  • Revised:February 01,2024
  • Online: July 04,2024
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