2025年6月26日 周四
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‘ The role of arachidonic acid derivatives in the development of abdominal aortic aneurysm
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Affiliation:

1.School of Pharmacy, East China University of Science and Technology & Shanghai Key Laboratory of New Drug Design, Shanghai 200237, China;2.Cardiology Department of Guang'anmen Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100053, China)

Clc Number:

R5

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    Abstract:

    Abdominal aortic aneurysm (AAA) is a common disease in the elderly, with an increasing incidence rate, easy rupture, high mortality, and no effective drugs to slow down the development of AAA. The pathogenesis of AAA is closely related to extracellular matrix degradation, apoptosis of vascular smooth muscle cells and inflammation. It has been found that arachidonic acid derivatives, especially prostaglandins such as prostaglandin E2 (PGE2), prostaglandin D2 (PGD2) and thromboxane A2(TXA2), play important roles in the development of AAA. Therefore, this review discusses the mechanism of arachidonic acid derivatives in the development of AAA, as well as the latest research progress of the drugs, to provide ideas for the treatment of AAA and the discovery of new drug targets.

    Reference
    [1] ‘YAMAGUCHI M, YONETSU T, HOSHINO M, et al.Clinical significance of increased computed tomography attenuation of periaortic adipose tissue in patients with abdominal aortic aneurysms.Circ J, 1,5(12):2172-2180.
    [2] ‘GOLLEDGE J.Abdominal aortic aneurysm:update on pathogenesis and medical treatments.Nat Rev Cardiol, 9,6(4):225-242.
    [3] ZHOU Y, KHAN H, XIAO J B, et al.Effects of arachidonic acid metabolites on cardiovascular health and disease.Int J Mol Sci, 1,2(21):12029.
    [4] 赵战芝, 吴鹏.黑色素瘤缺乏因子2在动脉粥样硬化和腹主动脉瘤中的作用.中国动脉硬化杂志, 2,0(10):913-920.ZHAO Z Z, WU P.The role of absent in melanoma 2 in atherosclerosis and abdominal aortic aneurysm.Chin J Arterioscler, 2,0(10):913-920.
    [5] ‘CAMERON S J, RUSSELL H M, OWENS A P 3RD.Antithrombotic therapy in abdominal aortic aneurysm:beneficial or detrimental?.Blood, 8,2(25):2619-2628.
    [6] YUAN Z, LU Y, WEI J, et al.Abdominal aortic aneurysm:roles of inflammatory cells.Front Immunol, 0,1:609161.
    [7] ‘FASOLO F, WINSKI G, LI Z L, et al.The circular RNA ataxia telangiectasia mutated regulates oxidative stress in smooth muscle cells in expanding abdominal aortic aneurysms.Mol Ther Nucleic Acids, 3,3:848-865.
    [8] 中华医学会外科学分会血管外科学组.腹主动脉瘤诊断和治疗中国专家共识(2022版).中国实用外科杂志, 2,2(4):380-387.Chinese Society for Vascular Surgery, Chinese Society of Surgery, Chinese Medical Association.Chinese expert consensus on the diagnosis and treatment of abdominal aortic aneurysm (2022 edition).Chin J Pract Surg, 2,2(4):380-387.
    [9] ‘BRADLEY N A, WALTER A, DOLAN R, et al.Evaluation of the prognostic value of computed tomography-derived body composition in patients undergoing endovascular aneurysm repair.J Cachexia Sarcopenia Muscle, 3,4(4):1836-1847.
    [10] GOLLEDGE J, THANIGAIMANI S, POWELL J T, et al.Pathogenesis and management of abdominal aortic aneurysm.Eur Heart J, 3,4(29):2682-2697.
    [11] WANG B, WU L J, CHEN J, et al.‘Metabolism pathways of arachidonic acids:mechanisms and potential therapeutic targets.Signal Transduct Target Ther, 1,6(1):94.
    [12] CAI Z J, ZHAO G, YAN J T, et al.CYP2J2 overexpression increases EETs and protects against angiotensin Ⅱ-induced abdominal aortic aneurysm in mice.J Lipid Res, 3,4(5):1448-1456.
    [13] ‘XU X Z, ZHANG X A, WANG D W.The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases.Adv Drug Deliv Rev, 1,3(8):597-609.
    [14] JONES A, DEB R, TORSNEY E, et al.Rosiglitazone reduces the development and rupture of experimental aortic aneurysms.Circulation, 9,9(24):3125-3132.
    [15] VILLARD C, HULTGREN R.Abdominal aortic aneurysm:sex differences.Maturitas, 8,9:63-69.
    [16] HOXHA M, BARBONETTI A, ZAPPACOSTA B.Arachidonic acid pathways and male fertility:a systematic review.Int J Mol Sci, 3,4(9):8207.
    [17] DAS U N.Is aortic aneurysm preventable?.J Transl Int Med, 7,5(2):72-78.
    [18] ‘AHLUWALIA N, LIN A Y, TAGER A M, et al.Inhibited aortic aneurysm formation in BLT1-deficient mice.J Immunol, 7,9(1):691-697.
    [19] HAEGGSTRM J Z, FUNK C D.Lipoxygenase and leukotriene pathways:biochemistry, biology, and roles in disease.Chem Rev, 1,1(10):5866-5898.
    [20] DI GENNARO A, ARAU＇JO A C, BUSCH A, et al.Cysteinyl leukotriene receptor 1 antagonism prevents experimental abdominal aortic aneurysm.Proc Natl Acad Sci U S A, 8,5(8):1907-1912.
    [21] ICHIYAMA T, KAJIMOTO M, HASEGAWA M, et al.Cysteinyl leukotrienes enhance tumour necrosis factor-alpha-induced matrix metalloproteinase-9 in human monocytes/macrophages.Clin Exp Allergy, 7,7(4):608-614.
    [22] ‘BHAMIDIPATI C M, WHATLING C A, MEHTA G S, et al.5-lipoxygenase pathway in experimental abdominal aortic aneurysms.Arterioscler Thromb Vasc Biol, 4,4(12):2669-2678.
    [23] ARAU＇JO A C, TANG X, HAEGGSTRM J Z.Targeting cysteinyl-leukotrienes in abdominal aortic aneurysm.Prostaglandins Other Lipid Mediat, 8,9:24-28.
    [24] POPE N H, SALMON M, DAVIS J P, et al.D-series resolvins inhibit murine abdominal aortic aneurysm formation and increase M2 macrophage polarization.FASEB J, 6,0(12):4192-4201.
    [25] MAEHARA T, HIGASHITARUMI F, KONDO R, et al.Prostaglandin F2α receptor antagonist attenuates LPS-induced systemic inflammatory response in mice.FASEB J, 0,4(11):15197-15207.
    [26] BADIMON L, VILAHUR G, ROCCA B, et al.The key contribution of platelet and vascular arachidonic acid metabolism to the pathophysiology of atherothrombosis.Cardiovasc Res, 1,7(9):2001-2015.
    [27] MITCHELL J A, KIRKBY N S.Eicosanoids, prostacyclin and cyclooxygenase in the cardiovascular system.Br J Pharmacol, 9,6(8):1038-1050.
    [28] ‘COURTOIS A, MAKRYGIANNIS G, CHERAMY-BIEN J P, et al.Therapeutic applications of prostaglandins and thromboxane A2 inhibitors in abdominal aortic aneurysms.Curr Drug Targets, 8,9(11):1247-1255.
    [29] BEIRNE C, HYNES N, SULTAN S.Six years' experience with prostaglandin I2 infusion in elective open repair of abdominal aortic aneurysm:a parallel group observational study in a tertiary referral vascular center.Ann Vasc Surg, 8,2(6):750-755.
    [30] ZUO S K, KONG D P, WANG C Y, et al.CRTH2 promotes endoplasmic reticulum stress-induced cardiomyocyte apoptosis through m-calpain.EMBO Mol Med, 8,0(3):e8237.
    [31] KONG D P, SHEN Y J, LIU G Z, et al.PKA regulatory Ⅱα subunit is essential for PGD2-mediated resolution of inflammation.J Exp Med, 6,3(10):2209-2226.
    [32] KONG D P, WAN Q Y, LI J J, et al.DP1 activation reverses age-related hypertension via NEDD4L-mediated T-bet degradation in T cells.Circulation, 0,1(8):655-666.
    [33] KONG D P, YU Y.Prostaglandin D2 signaling and cardiovascular homeostasis.J Mol Cell Cardiol, 2,7:97-105.
    [34] WEINTRAUB N L, BLOMKALNS A L, OGBI M, et al.Role of prostaglandin D2 receptors in the pathogenesis of abdominal aortic aneurysm formation.Clin Sci (Lond), 2,6(5):309-321.
    [35] WOODWARD D F, JONES R L, NARUMIYA S.International union of basic and clinical pharmacology.LXXXIII:classification of prostanoid receptors, updating 15 years of progress.Pharmacol Rev, 1,3(3):471-538.
    [36] YANG C, LIU X X, CAO Q, et al.Prostaglandin E receptors as inflammatory therapeutic targets for atherosclerosis.Life Sci, 1,8(5/6):201-205.
    [37] OWENS A P 3RD, EDWARDS T L, ANTONIAK S, et al.Platelet inhibitors reduce rupture in a mouse model of established abdominal aortic aneurysm.Arterioscler Thromb Vasc Biol, 5,5(9):2032-2041.
    [38] XU H, FANG B Y, BAO C Z, et al.The prostaglandin E2 receptor EP4 promotes vascular neointimal hyperplasia through translational control of tenascin C via the cAPM/PKA/mTORC1/rpS6 pathway.Cells, 2,1(17):2720.
    [39] PAVLOVIC S, DU B H, SAKAMOTO K, et al.‘Targeting prostaglandin E2 receptors as an alternative strategy to block cyclooxygenase-2-dependent extracellular matrix-induced matrix metalloproteinase-9 expression by macrophages.J Biol Chem, 6,1(6):3321-3328.
    [40] HIROMI T, YOKOYAMA U, KUROTAKI D, et al.Excessive EP4 signaling in smooth muscle cells induces abdominal aortic aneurysm by amplifying inflammation.Arterioscler Thromb Vasc Biol, 0,0(6):1559-1573.
    [41] TAKAYAMA K, SUKHOVA G K, CHIN M T, et al.A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling.Circ Res, 6,8(4):499-504.
    [42] GARGIULO S, ROSSIN D, TESTA G, et al.Up-regulation of COX-2 and mPGES-1 by 27-hydroxycholesterol and 4-hydroxynonenal:‘a crucial role in atherosclerotic plaque instability.Free Radic Biol Med, 8,9:354-363.
    [43] ‘AVENDAO M S, GARCA-REDONDO A B, ZALBA G, et al.mPGES-1 (microsomal prostaglandin E synthase-1) mediates vascular dysfunction in hypertension through oxidative stress.Hypertension, 8,2(2):492-502.
    [44] ZHAI Z Y, ZHANG X J, DING Y C, et al.Eugenol restrains abdominal aortic aneurysm progression with down-regulations on NF-κB and COX-2.Phytother Res, 2,6(2):928-937.
    [45] LIU B, KONG J, AN G P, et al.Regulatory T cells protected against abdominal aortic aneurysm by suppression of the COX-2 expression.J Cell Mol Med, 9,3(10):6766-6774.
    [46] MOLINA-SNCHEZ P, DEL CAMPO L, ESTEBAN V, et al.Defective p27 phosphorylation at serine 10 affects vascular reactivity and increases abdominal aortic aneurysm development via Cox-2 activation.J Mol Cell Cardiol, 8,6:5-15.
    [47] SOL-VILL D, DILM J F, RODRGUEZ C, et al.Expression and cellular localization of 15-hydroxy-prostaglandin-dehydrogenase in abdominal aortic aneurysm.PLoS One, 5,0(8):e0136201.
    [48] MUSIEK E S, GAO L, MILNE G L, et al.Cyclopentenone isoprostanes inhibit the inflammatory response in macrophages.J Biol Chem, 5,0(42):35562-35570.
    [49] MONTUSCHI P, BARNES P, ROBERTS L J 2ND.Insights into oxidative stress:the isoprostanes.Curr Med Chem, 7,4(6):703-717.
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JIAO Zhiang, CHANG Yueyue, MENG Shuo, MA Sijing, WANG Zhe, ZHANG Jian.‘ The role of arachidonic acid derivatives in the development of abdominal aortic aneurysm[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2024,32(5):437-443.

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History
  • Received:June 16,2023
  • Revised:September 25,2023
  • Online: May 09,2024
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