Advances in the role of miRNA in atherosclerosis associated with obstructive sleep apnea

Home > Archive>Volume 32, Issue 4, 2024 >364-368

Advances in the role of miRNA in atherosclerosis associated with obstructive sleep apnea
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                        ZHANG Sha1ZHANG Sha
The First Clinical Medical College of Lanzhou University,Lanzhou, Gansu 730000, China
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LIU Weiying2LIU Weiying
Department of Respiratory and Critical Care Medicine, the First Hospital of Lanzhou University, Lanzhou, Gansu 730000, China
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WANG Juan1WANG Juan
The First Clinical Medical College of Lanzhou University,Lanzhou, Gansu 730000, China
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FU Wenli1FU Wenli
The First Clinical Medical College of Lanzhou University,Lanzhou, Gansu 730000, China
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LI Leping1LI Leping
The First Clinical Medical College of Lanzhou University,Lanzhou, Gansu 730000, China
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Affiliation:1.The First Clinical Medical College of Lanzhou University,Lanzhou, Gansu 730000, China ;2.Department of Respiratory and Critical Care Medicine, the First Hospital of Lanzhou University, Lanzhou, Gansu 730000, China)
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Abstract:

Obstructive sleep apnea (OSA) is an independent risk factor for several cardiovascular diseases, and its characteristic intermittent hypoxic environment induces dysregulation of miRNA in cells and circulation, which promotes cellular dysfunction and metabolic disorders, and participates in the formation of atherosclerosis (As). This article reviews the potential role of miRNA in the occurrence and progression of OSA-related As, which helps to understand the molecular pathways underlying the pathogenesis of OSA-related As and provides new insights for the development of miRNA based therapies for OSA-related cardiovascular diseases.

Key words:miRNA; obstructive sleep apnea; atherosclerosis

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ZHANG Sha, LIU Weiying, WANG Juan, FU Wenli, LI Leping. Advances in the role of miRNA in atherosclerosis associated with obstructive sleep apnea[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2024,32(4):364-368.

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Received:September 07,2023
Revised:October 25,2023
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Online: April 29,2024
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