2025年5月25日 周日
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Macrophage ferroptosis and atherosclerosis
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1.Guangxi Key Laboratory of Diabetes System Medicine & Department of Histology and Embryology, Guilin Medical University, Guilin, Guangxi 541199, China;2.Guilin Medical College-Mingshun Pharmaceutical Joint Laboratory of Chronic Disease Control Research, Shaoyang, Hunan 422800, China)

Clc Number:

R54

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    Abstract:

    Atherosclerosis is the pathological basis of a variety of cardiovascular diseases, which are still the leading cause of human death worldwide. Ferroptosis is a kind of iron dependent non-apoptotic cell death mode, which is closely related to various physiological mechanisms. Recent studies have found that ferroptosis in macrophages plays an important role in the occurrence and development of atherosclerosis. Based on the imbalance of iron metabolism in macrophages, this paper reviews the correlation between ferroptosis in macrophages and atherosclerosis in terms of the interaction between ferroptosis in macrophages and lipid peroxidation, inflammation, oxidative stress, etc., in order to provide new ideas for the study of the pathogenesis of atherosclerosis.

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WANG Qiong, FENG Anni, YA Houdi, CHEN Yuhua, ZHENG Biao, MO Zhongcheng. Macrophage ferroptosis and atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2024,32(3):257-262.

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History
  • Received:May 19,2023
  • Revised:July 12,2023
  • Online: April 07,2024
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