Research progress on the role of circRNA in atherosclerosis and the regulation of traditional Chinese medicine
Author:
Affiliation:

Department of Rehabilitation Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China)

Clc Number:

R5

  • Article
  • | |
  • Metrics
  • |
  • Reference [61]
  • |
  • Related [20]
  • | | |
  • Comments
    Abstract:

    Circular RNA (circRNA), an emerging non-coding RNA, is closely related to the processes of lipid deposition, inflammatory response, apoptosis, proliferation and repair in atherosclerosis (As), and affects the development of As. Traditional Chinese medicine (TCM) has an important academic value in the prevention and treatment of As, and its regulatory mechanism has not been comprehensively summarized. This paper reviewed the association of circRNA with lipid deposition, inflammatory response and macrophage in As, and summarized the research progress of the correlation between circRNA and atherosclerosis and the regulation of traditional Chinese medicine.

    Reference
    [1] ROTH G A, MENSAH G A, JOHNSON C O, et al.Global burden of cardiovascular diseases and risk factors, 1990—2019:update from the GBD 2019 study.J Am Coll Cardiol, 0,6(25):2982-3021.
    [2] CAO D Y, KHAN Z, LI X M, et al.Macrophage angiotensin-converting enzyme reduces atherosclerosis by increasing peroxisome proliferator-activated receptor α and fundamentally changing lipid metabolism.Cardiovasc Res, 3,9(9):1825-1841.
    [3] BAIDAJEVAS K, HADADI , LEE B, et al.Macrophage polarisation associated with atherosclerosis differentially affects their capacity to handle lipids.Atherosclerosis, 0,5:10-18.
    [4] ZHANG X, BISHAWI M, ZHANG G, et al.Modeling early stage atherosclerosis in a primary human vascular microphysiological system.Nat Commun, 0,1(1):5426.
    [5] KIRICHENKO T V, SUKHORUKOV V N, MARKIN A M, et al.Medicinal plants as a potential and successful treatment option in the context of atherosclerosis.Front Pharmacol, 0,1:403.
    [6] DJEBALI S, DAVIS C A, MERKEL A, et al.Landscape of transcription in human cells.Nature, 2,9(7414):101-108.
    [7] HSU M T, COCA-PRADOS M.Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells.Nature, 9,0(5720):339-340.
    [8] SANGER H L, KLOTZ G, RIESNER D, et al.Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures.Proc Natl Acad Sci U S A, 6,3(11):3852-3856.
    [9] DAS A, SINHA T, MISHRA S S, et al.Identification of potential proteins translated from circular RNA splice variants.Eur J Cell Biol, 3,2(1):151286.
    [10] KRISTENSEN L S, ANDERSEN M S, STAGSTED L V W, et al.The biogenesis, biology and characterization of circular RNAs.Nat Rev Genet, 9,0(11):675-691.
    [11] CHEN I, CHEN C Y, CHUANG T J.Biogenesis, identification, and function of exonic circular RNAs.Wiley Interdiscip Rev RNA, 5,6(5):563-579.
    [12] GOKOOL A, ANWAR F, VOINEAGU I.The landscape of circular RNA expression in the human brain.Biol Psychiatry, 0,7(3):294-304.
    [13] CAO Q D, GUO Z Y, DU S S, et al.Circular RNAs in the pathogenesis of atherosclerosis.Life Sci, 0,5:117837.
    [14] DONG K Z, HE X Q, SU H B, et al.Genomic analysis of circular RNAs in heart.BMC Med Genomics, 0,3(1):167.
    [15] ZHANG F, JIANG J J, QIAN H, et al.Exosomal circRNA:emerging insights into cancer progression and clinical application potential.J Hematol Oncol, 3,6(1):67.
    [16] ZHOU W Y, CAI Z R, LIU J, et al.Circular RNA:metabolism, functions and interactions with proteins.Mol Cancer, 0,9(1):172.
    [17] FASOLO F, DI GREGOLI K, MAEGDEFESSEL L, et al.Non-coding RNAs in cardiovascular cell biology and atherosclerosis.Cardiovasc Res, 9,5(12):1732-1756.
    [18] HOLDT L M, STAHRINGER A, SASS K, et al.Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans.Nat Commun, 6,7:12429.
    [19] MOORE K J, SHEEDY F J, FISHER E A.Macrophages in atherosclerosis:a dynamic balance.Nat Rev Immunol, 3,3(10):709-721.
    [20] MAO C Y, LI D J, ZHOU E, et al.Nicotine exacerbates atherosclerosis through a macrophage-mediated endothelial injury pathway.Aging (Albany NY), 1,3(5):7627-7643.
    [21] WU W P, ZHOU M Y, LIU D L, et al.CircGNAQ, a circular RNA enriched in vascular endothelium, inhibits endothelial cell senescence and atherosclerosis progression.Mol Ther Nucleic Acids, 1,6:374-387.
    [22] ABE R J, ABE J I, NGUYEN M T H, et al.Free cholesterol bioavailability and atherosclerosis.Curr Atheroscler Rep, 2,4(5):323-336.
    [23] 温雯, 张建勋, 高奋.环状RNA调节脂质代谢在动脉粥样硬化中的作用.中国动脉硬化杂志, 1,9(3):217-221.WEN W, ZHANG J X, GAO F.The role of circRNA in regulating lipid metabolism in atherosclerosis.Chin J Arterioscler, 1,9(3):217-221.
    [24] LIU K Q, LIU X, DENG Y Q, et al.CircRNA-mediated regulation of brown adipose tissue adipogenesis.Front Nutr, 2,9:926024.
    [25] HE Q, SHAO D D, HAO S Y, et al.CircSCAP aggravates oxidized low-density lipoprotein-induced macrophage injury by upregulating PDE3B by miR-221-5p in atherosclerosis.J Cardiovasc Pharmacol, 1,8(5):e749-e760.
    [26] XU F, SHEN L, CHEN H, et al.CircDENND1B participates in the antiatherosclerotic effect of IL-1β monoclonal antibody in mouse by promoting cholesterol efflux via miR-17-5p/ABCA1 axis.Front Cell Dev Biol, 1,9:652032.
    [27] YU X P, TONG H J, CHEN J L, et al.CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export.Cell Death Dis, 3,4(1):20.
    [28] LIN X H, DU Y, LU W N, et al.CircRNF111 protects against insulin resistance and lipid deposition via regulating miR-143-3p/IGF2R axis in metabolic syndrome.Front Cell Dev Biol, 1,9:663148.
    [29] LIBBY P.Inflammation during the life cycle of the atherosclerotic plaque.Cardiovasc Res, 1,7(13):2525-2536.
    [30] ANDERSON T J.Assessment and treatment of endothelial dysfunction in humans.J Am Coll Cardiol, 9,4(3):631-638.
    [31] TONG K L, TAN K E, LIM Y Y, et al.CircRNA-miRNA interactions in atherogenesis.Mol Cell Biochem, 2,7(12):2703-2733.
    [32] QIAO S, WANG X, LI H Y, et al.Atherosclerosis-associated endothelial dysfunction is promoted by miR-199a-5p/SIRT1 axis regulated by circHIF1α.Nutr Metab Cardiovasc Dis, 3,3(8):1619-1631.
    [33] ZHANG M, ZHU Y Q, ZHU J, et al.Circ_0086296 induced atherosclerotic lesions via the IFIT1/STAT1 feedback loop by sponging miR-576-3p.Cell Mol Biol Lett, 2,7(1):80.
    [34] XU S K, GE Y S, WANG X B, et al.Circ-USP9X interacts with EIF4A3 to promote endothelial cell pyroptosis by regulating GSDMD stability in atherosclerosis.Clin Exp Hypertens, 3,5(1):2186319.
    [35] YU F P, ZHANG Y, WANG Z Z, et al.Hsa_circ_0030042 regulates abnormal autophagy and protects atherosclerotic plaque stability by targeting eIF4A3.Theranostics, 1,1(11):5404-5417.
    [36] YE B Z, LIANG X H, ZHAO Y H, et al.Hsa_circ_0007478 aggravates NLRP3 inflammasome activation and lipid metabolism imbalance in ox-LDL-stimulated macrophage via miR-765/EFNA3 axis.Chem Biol Interact, 2,8:110195.
    [37] LI R G, JIANG Q L, ZHENG Y.Circ_0002984 induces proliferation, migration and inflammation response of VSMCs induced by ox-LDL through miR-326-3p/VAMP3 axis in atherosclerosis.J Cell Mol Med, 1,5(16):8028-8038.
    [38] XU Y B, HUANG Y L, ZHANG S Y, et al.CircDCLRE1C regulated lipopolysaccharide-induced inflammatory response and apoptosis by regulating miR-214b-3p/STAT3 pathway in macrophages.Int J Mol Sci, 2,3(12):6822.
    [39] GENG Y J, LIBBY P.Evidence for apoptosis in advanced human atheroma.Colocalization with interleukin-1 beta-converting enzyme.Am J Pathol, 5,7(2):251-266.
    [40] GAUTIER E L, HUBY T, WITZTUM J L, et al.Macrophage apoptosis exerts divergent effects on atherogenesis as a function of lesion stage.Circulation, 9,9(13):1795-1804.
    [41] SUN X, GUO S Y, YAO J T, et al.Rapid inhibition of atherosclerotic plaque progression by sonodynamic therapy.Cardiovasc Res, 9,5(1):190-203.
    [42] LIU H F, MA X W, WANG X, et al.Hsa_circ_0000345 regulates the cellular development of ASMCs in response to oxygenized low-density lipoprotein.J Cell Mol Med, 0,4(20):11849-11857.
    [43] GUO M, YAN R, JI Q W, et al.IFN regulatory factor-1 induced macrophage pyroptosis by modulating m6A modification of circ_0029589 in patients with acute coronary syndrome.Int Immunopharmacol, 0,6:106800.
    [44] WU J Y, HE S P, SONG Z K, et al.Macrophage polarization states in atherosclerosis.Front Immunol, 3,4:1185587.
    [45] HE P K, WANG H, CHENG S B, et al.Geniposide ameliorates atherosclerosis by regulating macrophage polarization via perivascular adipocyte-derived CXCL14.J Ethnopharmacol, 3,4:116532.
    [46] STGER J L, GIJBELS M J J, VAN DER VELDEN S, et al.Distribution of macrophage polarization markers in human atherosclerosis.Atherosclerosis, 2,5(2):461-468.
    [47] YANG S, YUAN H Q, HAO Y M, et al.Macrophage polarization in atherosclerosis.Clin Chim Acta, 0,1:142-146.
    [48] WAN L, LIU J, HUANG C B, et al.Role of m6A modification and novel circ_0066715/miR-486-5p/ETS1 axis in rheumatoid arthritis macrophage polarization progression.Aging (Albany NY), 2,4(24):10009-10026.
    [49] LU C, SHI W, HU W J, et al.Endoplasmic reticulum stress promotes breast cancer cells to release exosomes circ_0001142 and induces M2 polarization of macrophages to regulate tumor progression.Pharmacol Res, 2,7:106098.
    [50] LI S Z, HAO M H, WU T S, et al.Kaempferol alleviates human endothelial cell injury through circNOL12/miR-6873-3p/FRS2 axis.Biomed Pharmacother, 1,7:111419.
    [51] WANG X C, MA C, HOU X J, et al.Circular RNA circ_0002984 promotes cell proliferation and migration by regulating miR-181b-5p/vascular endothelial growth factor axis and PI3K-Akt signaling pathway in oxidized low-density lipoprotein-treated vascular smooth muscle cells.J Cardiovasc Pharmacol, 2,9(4):501-511.
    [52] ZHOU W Y, WANG F, QIAN X S, et al.Quercetin protects endothelial function from inflammation induced by localized disturbed flow by inhibiting NRP2-VEGFC complex.Int Immunopharmacol, 3,6:109842.
    [53] LI H X, XIAO L, HE H, et al.Quercetin attenuates atherosclerotic inflammation by inhibiting galectin-3-NLRP3 signaling pathway.Mol Nutr Food Res, 1,5(15):e2000746.
    [54] XUAN Y, YU C, NI K, et al.Protective effects of tanshinone IIA on Porphyromonas gingivalis-induced atherosclerosis via the downregulation of the NOX2/NOX4-ROS mediation of NF-κB signaling pathway.Microbes Infect, 3,5(8):105177.
    [55] CHEN W N, GUO S N, LI X M, et al.The regulated profile of noncoding RNAs associated with inflammation by tanshinone IIA on atherosclerosis.J Leukoc Biol, 0,8(1):243-252.
    [56] ZHANG S S, LONG F Y, LIN H, et al.Regulatory roles of phytochemicals on circular RNAs in cancer and other chronic diseases.Pharmacol Res, 1,4:105936.
    [57] LIU X F, WU J S, TIAN R M, et al.Targeting foam cell formation and macrophage polarization in atherosclerosis:the therapeutic potential of rhubarb.Biomed Pharmacother, 0,9:110433.
    [58] CAO H, JIA Q L, SHEN D Z, et al.Bushen Jiangzhi formula reduces atherosclerosis in ApoE-/- mice through autophagy.J Tradit Chin Med, 0,0(4):593-601.
    [59] YAN L, JIA Q L, CAO H, et al.Effect of Bushen Jiangzhi recipe on atherosclerosis in ApoE-/- mice by regulating the expression of Anpep via mmu_circRNA_22187.Evid Based Complement Alternat Med, 1,1:4738264.
    [60] ZHENG S S, HUANG H, LI Y Z, et al.Yin-xing-tong-mai decoction attenuates atherosclerosis via activating PPARγ-LXRα-ABCA1/ABCG1 pathway.Pharmacol Res, 1,9:105639.
    [61] 吕昕儒, 魏伟, 王夏蕾, 等.基于胆固醇逆转运探讨泽泻白术配伍改善ApoE-/-小鼠动脉粥样硬化的作用.中国动脉硬化杂志, 1,9(4):286-294.LYU X R, WEI W, WANG X L, et al.To explore effect of Alisma combined with Atractylodes macrocephala on atherosclerosis in ApoE-/-mice with reverse cholesterol transport.Chin J Arterioscler, 1,9(4):286-294.
    Cited by
    Comments
    Comments
    分享到微博
    Submit
Get Citation

HUANG Bingyu, GUO Zhiyan, LIU Ying. Research progress on the role of circRNA in atherosclerosis and the regulation of traditional Chinese medicine[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2024,32(2):164-170.

Copy
Share
Article Metrics
  • Abstract:255
  • PDF: 818
  • HTML: 0
  • Cited by: 0
History
  • Received:August 16,2023
  • Revised:September 30,2023
  • Online: February 22,2024
Article QR Code