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Ferroptosis and atherosclerosis
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1.Institute of Pharmaceutical Pharmacology, School of Pharmacy, University of South China, ;2.Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China)

Clc Number:

R5；R363

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    Abstract:

    Ferroptosis is defined as an iron-dependent regulated form of cell death driven by lipid peroxidation, which is not only regulated by a variety of cellular metabolic pathways, but it is also related to neurodegenerative diseases, tumors, cardiovascular diseases and so on. Recent studies have found that ferroptosis plays a crucial part in the process of atherosclerosis. This article reviews the role and molecular mechanism of ferroptosis in the pathological processes of atherosclerosis, such as vascular endothelial cell dysfunction, macrophage polarization, foam cell formation, vascular smooth muscle cell proliferation and migration, and summarizes the ferroptosis inhibitors and related targets that may have therapeutic effects on atherosclerosis. The aim is to provide a new therapeutic direction for atherosclerosis from the perspective of ferroptosis.

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WANG Liwen, LIU Huimei, LI Lanfang, HU Xiaobo. Ferroptosis and atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2024,32(2):155-163.

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History
  • Received:May 29,2023
  • Revised:July 10,2023
  • Online: February 22,2024
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