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Research progress on the role of HIF-1α in atherosclerosis
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Affiliation:

1.Henan University of Chinese Medicine, Zhengzhou, Henan 450099, China;2.Heart Center of the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan 450000,China)

Clc Number:

R5；R363

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    Abstract:

    The hypoxia inducible factor-1α (HIF-1α) is a major regulator of the cellular response to hypoxia, and its high expression is induced in the hypoxic environment of atherosclerosis (As) plaques. It is a key protein to promote the progression of As and widely involved in the occurrence and development of As. This article reviews the structure and function of HIF-1α and its role in endothelial cells, vascular smooth muscle cells, mononuclear macrophages and the differentiation of CD4＋T cells, in order to provide new ideas for the prevention and treatment of As based on HIF-1α.

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YUAN Mingchuan, WANG Li, WANG He, CHEN Yushan, GUAN Huaimin. Research progress on the role of HIF-1α in atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2023,31(9):815-820.

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History
  • Received:March 05,2023
  • Revised:April 20,2023
  • Online: October 19,2023
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