Advances in selective autophagy and atherosclerosis
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Institute of Pharmaceutical Pharmacology, School of Pharmacy, University of South China, Hengyang, Hunan 421001, China)

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R5;R363

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    Abstract:

    Selective autophagy is specific to degraded substrate proteins, including mitophagy, lipophagy, inflammasomophagy, reticulophagy, pexophagy, aggrephagy and ribophagy, etc. Atherosclerosis (As) is a chronic inflammatory disease mainly characterized by lipid accumulation, foam cell formation, endothelial cell dysfunction, abnormal proliferation of vascular smooth muscle cell, and local inflammation. In recent years, a large number of studies have suggested that selective autophagy is involved in the development of As. This paper reviewed the regulatory mechanisms of selective autophagy, and the potential roles of mitophagy, lipophagy, inflammasomophagy, reticulophagy and pexophagy in As, which can provide new ideas for the treatment of As.

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LIU Huimei, PENG Guolong, OUYANG Xueqian, LI Lanfang. Advances in selective autophagy and atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2023,31(9):737-745, 753.

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History
  • Received:December 20,2022
  • Revised:January 26,2023
  • Online: October 19,2023
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