Protein palmitoylation and cardiovascular disease

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Protein palmitoylation and cardiovascular disease
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                        FAN SisiFAN Sisi
Institute of Pharmacy and Pharmacology, University of South China & Institute of Cardiovascular Disease, University of South China & Key Laboratory for Arteriosclerology of Hunan Province & International Laboratory for Scientific Innovation and Co-operation of Hunan Province, Hengyang, Hunan 421001, China
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WANG LiwenWANG Liwen
Institute of Pharmacy and Pharmacology, University of South China & Institute of Cardiovascular Disease, University of South China & Key Laboratory for Arteriosclerology of Hunan Province & International Laboratory for Scientific Innovation and Co-operation of Hunan Province, Hengyang, Hunan 421001, China
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LI QinLI Qin
Institute of Pharmacy and Pharmacology, University of South China & Institute of Cardiovascular Disease, University of South China & Key Laboratory for Arteriosclerology of Hunan Province & International Laboratory for Scientific Innovation and Co-operation of Hunan Province, Hengyang, Hunan 421001, China
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LI LanfangLI Lanfang
Institute of Pharmacy and Pharmacology, University of South China & Institute of Cardiovascular Disease, University of South China & Key Laboratory for Arteriosclerology of Hunan Province & International Laboratory for Scientific Innovation and Co-operation of Hunan Province, Hengyang, Hunan 421001, China
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JIANG ZhishengJIANG Zhisheng
Institute of Pharmacy and Pharmacology, University of South China & Institute of Cardiovascular Disease, University of South China & Key Laboratory for Arteriosclerology of Hunan Province & International Laboratory for Scientific Innovation and Co-operation of Hunan Province, Hengyang, Hunan 421001, China
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Affiliation:Institute of Pharmacy and Pharmacology, University of South China & Institute of Cardiovascular Disease, University of South China & Key Laboratory for Arteriosclerology of Hunan Province & International Laboratory for Scientific Innovation and Co-operation of Hunan Province, Hengyang, Hunan 421001, China)
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Abstract:

Protein palmitoylation is a kind of post-translational lipid modification of proteins that widely exists in organisms. Generally, S-palmitoylation occurs mainly through the covalent attachment of palmitic acid to protein-specific cysteine residues via labile thioester linkages. S-palmitoylation is usually reversible because the thioester bond will be hydrolyzed under certain conditions, causing protein depalmitoylation. In addition, S-palmitoylation is closely associated with the occurrence and development of many cardiovascular diseases. This review summarizes the process of protein palmitoylation and depalmitoylation, the relationship between protein palmitoylation and cardiovascular diseases, including arrhythmia, atherosclerosis, pulmonary hypertension, heart failure, and thrombotic diseases, which provide a new direction for cardiovascular disease treatment.

Key words:protein palmitoylation; protein acyltransferase; acyl protein thioesterase; palmitoyl protein thioesterase; cardiovascular disease

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FAN Sisi, WANG Liwen, LI Qin, LI Lanfang, JIANG Zhisheng. Protein palmitoylation and cardiovascular disease[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2023,31(8):645-653.

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Received:February 08,2023
Revised:April 24,2023
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Online: July 20,2023
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