Atherosclerosis (As), a complex chronic inflammatory disease, that is a major cause of cardiovascular diseases (CVD) including ischemic heart disease and stroke, causing high morbidity and mortality worldwide. In recent years, the role of gut microbiota in atherosclerosis has received extensive attention. However, as an important anti-atherosclerosis beneficial bacteria, Akkermansia is rarely reviewed. In-depth study of the pathogenesis and potential treatment of atherosclerosis is the focus of current medical development. Therefore, this article reviews how Akkermansia exerts its anti-atherosclerotic effect and its relationship with anti-atherosclerotic drugs.