Macrophages calpain promotes the progression of atherosclerosis

doi:10.20039/j.cnki.1007 3949.2023.05.012

Home > Archive>Volume 31, Issue 5, 2023 >449-455. DOI:10.20039/j.cnki.1007 3949.2023.05.012

Macrophages calpain promotes the progression of atherosclerosis
DOI:
                        10.20039/j.cnki.1007 3949.2023.05.012
                    
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                        LUO ShiyuLUO Shiyu
Institute of Pharmacy & Pharmacology, Hengyang Medical School, University of South China, Hengyang, Hunan 421001,China
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YE ShiyingYE Shiying
Institute of Pharmacy & Pharmacology, Hengyang Medical School, University of South China, Hengyang, Hunan 421001,China
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ZHANG YalingZHANG Yaling
Institute of Pharmacy & Pharmacology, Hengyang Medical School, University of South China, Hengyang, Hunan 421001,China
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GAO YiGAO Yi
Institute of Pharmacy & Pharmacology, Hengyang Medical School, University of South China, Hengyang, Hunan 421001,China
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YUAN BichenYUAN Bichen
Institute of Pharmacy & Pharmacology, Hengyang Medical School, University of South China, Hengyang, Hunan 421001,China
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SUN ShaoweiSUN Shaowei
Institute of Pharmacy & Pharmacology, Hengyang Medical School, University of South China, Hengyang, Hunan 421001,China
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Affiliation:Institute of Pharmacy & Pharmacology, Hengyang Medical School, University of South China, Hengyang, Hunan 421001,China)
Clc Number:R363；R5
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Abstract:

Atherosclerosis (As) is a lipid-driven chronic inflammatory vascular disease, the pathogenesis of which primarily includes lipid metabolism disorders and inflammatory responses. Calpain, a calcium-dependent cysteine protease, has been shown to be involved in the development of As. Especially calpain in macrophages plays an important role in regulating lipid metabolism and inflammatory responses in As. This article reviews the possible pathways and molecular mechanisms of macrophages calpain involvement in As trying to provide new ideas for the prevention and treatment of As.

Key words:atherosclerosis; calpain; macrophages; lipid metabolism; inflammatory responses

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LUO Shiyu, YE Shiying, ZHANG Yaling, GAO Yi, YUAN Bichen, SUN Shaowei. Macrophages calpain promotes the progression of atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2023,31(5):449-455.

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Received:September 13,2022
Revised:October 18,2022
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Online: May 19,2023
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