The role of ferroptosis in the pathogenesis of hypertension

doi:10.20039/j.cnki.1007 3949.2023.05.011

Home > Archive>Volume 31, Issue 5, 2023 >441-448. DOI:10.20039/j.cnki.1007 3949.2023.05.011

The role of ferroptosis in the pathogenesis of hypertension
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                        10.20039/j.cnki.1007 3949.2023.05.011
                    
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                        GAN Ni1,2GAN Ni
Changsha Central Hospital Afiliated to University of South China, Changsha, Hunan 410004, China;Institute of Cardiovascular Disease, University of South China ＆ Key Laboratory for Arteriosclerology of Hunan Province ＆ Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang, Hunan 421001, China
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CUI Yuting2CUI Yuting
Institute of Cardiovascular Disease, University of South China ＆ Key Laboratory for Arteriosclerology of Hunan Province ＆ Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang, Hunan 421001, China
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ZHOU Yating2ZHOU Yating
Institute of Cardiovascular Disease, University of South China ＆ Key Laboratory for Arteriosclerology of Hunan Province ＆ Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang, Hunan 421001, China
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XIANG Qiong2XIANG Qiong
Institute of Cardiovascular Disease, University of South China ＆ Key Laboratory for Arteriosclerology of Hunan Province ＆ Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang, Hunan 421001, China
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PENG Juan2PENG Juan
Institute of Cardiovascular Disease, University of South China ＆ Key Laboratory for Arteriosclerology of Hunan Province ＆ Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang, Hunan 421001, China
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TANG Zhihan2TANG Zhihan
Institute of Cardiovascular Disease, University of South China ＆ Key Laboratory for Arteriosclerology of Hunan Province ＆ Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang, Hunan 421001, China
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Affiliation:1.Changsha Central Hospital Afiliated to University of South China, Changsha, Hunan 410004, China;2.Institute of Cardiovascular Disease, University of South China ＆ Key Laboratory for Arteriosclerology of Hunan Province ＆ Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang, Hunan 421001, China)
Clc Number:R5
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Abstract:

Ferroptosis is a newly discovered iron-dependent mode of programmed cell death, characterized by intracellular iron overload, glutathione depletion and lipid peroxidation. Hypertension is one of the important risk factors for the occurrence of cardiovascular and cerebrovascular diseases, and more and more studies have shown that hypertension is closely related to ferroptosis. This article will review the association between ferroptosis and hypertension, as well as the possible mechanisms of ferroptosis affecting hypertension, in order to provide new ideas for the treatment of hypertension.

Key words:hypertension; ferroptosis; iron metabolism; amino acid metabolism; lipid peroxidation; mitochondrial dysfunction

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GAN Ni, CUI Yuting, ZHOU Yating, XIANG Qiong, PENG Juan, TANG Zhihan. The role of ferroptosis in the pathogenesis of hypertension[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2023,31(5):441-448.

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Received:January 04,2023
Revised:March 09,2023
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Online: May 19,2023
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