Aim To explore the clinical value of transcutaneous oxygen pressure (TcPO₂) combined with serum oxidized low density lipoprotein (ox-LDL) in predicting restenosis after interventional therapy for lower arteriosclerosis obliterans (LASO). Methods 113 patients with LASO underwent interventional therapy in Yueyang Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from January 2020 to June 2021 were enrolled, and classified into non-stenosis group (n＝79) and restenosis group (n＝34) according to the occurrence of restenosis 1 year after interventional treatment. Serum ox-LDL levels were detected by ELISA and corresponding assay kits, and TcPO₂ was measured by laser Doppler flowmeter. Then comparison was conducted on general data, TcPO₂ and ox-LDL. Multivariate Logistic regression model was used to screen the influencing factors of restenosis after intervention therapy for LASO. Spearman test was used for correlation analysis, ROC curve was used to evaluate the efficacy of TcPO₂ and ox-LDL in predicting restenosis in LASO patients after intervention therapy. Results There was no significant difference between the two groups in age, body mass index (BMI), sex, alcohol consumption, history of cerebrovascular disease and coronary heart disease, number of diseased vessels, fasting blood glucose, and homocysteine (P＞0.05). Compared with the non-stenosis group, smoking, irregular drug use, the number of implanted stents, ox-LDL, and the level of blood uric acid in the restenosis group were significantly higher (P＜0.05), and TcPO₂ was significantly lower (P＜0.05). Logistic regression model analysis showed that smoking, irregular drug use after LASO intervention, large number of implanted stents, decreased TcPO₂, ox-LDL, and increased blood uric acid were the risk factors for restenosis after LASO intervention (P＜0.05). Spearman test showed that ox-LDL was positively correlated with restenosis after LASO intervention (r＝0.513, P＜0.001), and TcPO₂ was negatively correlated with it (r＝－0.524, P＜0.001). The ROC curve showed that the predictive efficacy of TcPO₂＋ox-LDL in predicting restenosis after LASO interventional therapy (AUC＝0.802) was higher than that of each indicator alone. The predictive sensitivity and specificity were 67.60% and 94.90% respectively, and the critical point was 37.23 mmHg and 5.31 mmol/L. Conclusion TcPO₂ is decreased and ox-LDL is increased in patients with restenosis after interventional therapy for LASO, both indicators have certain predictive value for restenosis, and combined detection of the two can reflect restenosis condition more completely.