Gasotransmitters are a class of endogenous signal transduction molecules with low-molecular weight, which can freely permeable to biological membranes of cells. As such, their intercellular and intracellular movements do not exclusively rely on membrane receptors or other transporters. Gasotransmitters have multiple molecular effects with a diversity of mechanisms, and researches of them have always been hotspots in the cardiovascular field. This review will introduce the research progressions of gasotransmitters in atherosclerosis, with emphasis on nitric oxide, carbon monoxide and hydrogen sulfide.