Research progress on the effects of exercise training on cardiovascular and metabolic diseases

doi:10.20039/j.cnki.10073949.2023.04.001

Home > Archive>Volume 31, Issue 4, 2023 >277-286. DOI:10.20039/j.cnki.10073949.2023.04.001

Research progress on the effects of exercise training on cardiovascular and metabolic diseases
DOI:
                        10.20039/j.cnki.10073949.2023.04.001
                    
CSTR:
                        
                    
Author:
                        FANG Wenqian1,2FANG Wenqian
Nantong Hospital Affiliated to Shanghai University & Sixth Peoples Hospital of Nantong & Exercise Training and Cardiovascular Health Laboratory, Shanghai University Institute of Geriatrics, Nantong, Jiangsu 226011, China;Shanghai University & Shanghai Engineering Research Center of Organ Repair & Cardiac Regeneration and Ageing Laboratory, Institute of Cardiovascular Sciences, Shanghai University, Shanghai 200444, China
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
XIAO Junjie1,2XIAO Junjie
Nantong Hospital Affiliated to Shanghai University & Sixth Peoples Hospital of Nantong & Exercise Training and Cardiovascular Health Laboratory, Shanghai University Institute of Geriatrics, Nantong, Jiangsu 226011, China;Shanghai University & Shanghai Engineering Research Center of Organ Repair & Cardiac Regeneration and Ageing Laboratory, Institute of Cardiovascular Sciences, Shanghai University, Shanghai 200444, China
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site

                    
Affiliation:1.Nantong Hospital Affiliated to Shanghai University & Sixth People's Hospital of Nantong & Exercise Training and Cardiovascular Health Laboratory, Shanghai University Institute of Geriatrics, Nantong, Jiangsu 226011, China;2.Shanghai University & Shanghai Engineering Research Center of Organ Repair & Cardiac Regeneration and Ageing Laboratory, Institute of Cardiovascular Sciences, Shanghai University, Shanghai 200444, China)
Clc Number:R5
Fund Project:

Article

Figures

Metrics

Reference [76]

Related [20]

Cited by

Materials

Comments

Abstract:

The prevalence of cardiovascular and metabolic diseases is increasing all over the world, and the social and economic burden caused by it is increasing. It has become a major public health problem for mankind. In recent years, a large amount of evidence shows that proper exercise training can prevent and treat cardiovascular and metabolic diseases. This paper reviews the molecular mechanism and therapeutic value of exercise training in cardiovascular diseases such as pathological myocardial hypertrophy, myocardial infarction, cardiomyopathy, heart failure and atherosclerosis, and metabolic diseases such as obesity, diabetes and fatty liver, in order to provide evidence and ideas for further research on prevention and treatment of cardiovascular and metabolic diseases based on exercise training.

Key words:exercise training; cardiovascular disease; metabolic disease; prevention; treatment

Reference

[1] NATALI A J, TURNER D L, HARRISON S M, et al.Regional effects of voluntary exercise on cell size and contraction-frequency responses in rat cardiac myocytes.J Exp Biol, 1,4(Pt 6):1191-1199.

[2] BOSTROM P, MANN N, WU J, et al.C/EBP beta controls exercise-induced cardiac growth and protects against pathological cardiac remodeling.Cell, 0,3(7):1072-1083.

[3] NERI SERNERI G G, BODDI M, MODESTI P A, et al.Increased cardiac sympathetic activity and insulin-like growth factor-I formation are associated with physiological hypertrophy in athletes.Circ Res, 1,9(11):977-982.

[4] KIM J, WENDE A R, SENA S, et al.Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy.Mol Endocrinol, 8,2(11):2531-2543.

[5] MCMULLEN J R, SHIOI T, HUANG W Y, et al.The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase (p110 alpha) pathway.J Biol Chem, 4,9(6):4782-4793.

[6] DEBOSCH B, TRESKOV I, LUPU T S, et al.Akt1 is required for physiological cardiac growth.Circulation, 6,3(17):2097-2104.

[7] CLEMENTE C F, XAVIER-NETO J, DALLA COSTA A P, et al.Focal adhesion kinase governs cardiac concentric hypertrophic growth by activating the AKT and mTOR pathways.J Mol Cell Cardiol, 2,2(2):493-501.

[8] ZOU J, LI H, CHEN X, et al.C/EBP beta knockdown protects cardiomyocytes from hypertrophy via inhibition of p65-NF kappa B.Mol Cell Endocrinol, 4,0(1-2):18-25.

[9] KUNISADA K, NEGORO S, TONE E, et al.Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy.Proc Natl Acad Sci USA, 0,7(1):315-319.

[10] CITTADINI A, MONTI M G, IACCARINO G, et al.SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the GP130/JAK/STAT pathway.Cardiovasc Res, 2,6(3):381-390.

[11] XU T, ZHOU Q, ZHOU J, et al.Carboxyl terminus of Hsp70-interacting protein (CHIP) contributes to human glioma oncogenesis.Cancer Sci, 1,2(5):959-966.

[12] LIU X, XIAO J, ZHU H, et al.miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling.Cell Metab, 5,1(4):584-595.

[13] SHI J, BEI Y, KONG X, et al.miR-17-3p contributes to exercise-induced cardiac growth and protects against myocardial ischemia-reperfusion injury.Theranostics, 7,7(3):664-676.

[14] GAO R, WANG L, BEI Y, et al.Long noncoding RNA cardiac physiological hypertrophy-associated regulator induces cardiac physiological hypertrophy and promotes functional recovery after myocardial ischemia-reperfusion injury.Circulation, 1,4(4):303-317.

[15] LIN H, ZHU Y, ZHENG C, et al.Antihypertrophic memory after regression of exercise-induced physiological myocardial hypertrophy is mediated by the long noncoding RNA Mhrt779.Circulation, 1,3(23):2277-2292.

[16] LI H, TRAGER L E, LIU X, et al.lncExACT1 and DCHS2 regulate physiological and pathological cardiac growth.Circulation, 2,5(16):1218-1233.

[17] LIAO J, LI Y, ZENG F, et al.Regulation of mTOR pathway in exercise-induced cardiac hypertrophy.Int J Sports Med, 5,6(5):343-350.

[18] YANG F, YOU X, XU T, et al.Screening and function analysis of microRNAs involved in exercise preconditioning-attenuating pathological cardiac hypertrophy.Int Heart J, 8,9(5):1069-1076.

[19] SERRA A J, HIGUCHI M L, IHARA S S, et al.Exercise training prevents beta-adrenergic hyperactivity-induced myocardial hypertrophy and lesions.Eur J Heart Fail, 8,0(6):534-539.

[20] SILVA J A J R, SANTANA E T, MANCHINI M T, et al.Exercise training can prevent cardiac hypertrophy induced by sympathetic hyperactivity with modulation of kallikrein-kinin pathway and angiogenesis.PLoS One, 4,9(3):e91017.

[21] XU T, TANG H, ZHANG B, et al.Exercise preconditioning attenuates pressure overload-induced pathological cardiac hypertrophy.Int J Clin Exp Pathol, 5,8(1):530-540.

[22] REN J, YANG L, TIAN W, et al.Nitric oxide synthase inhibition abolishes exercise-mediated protection against isoproterenol-induced cardiac hypertrophy in female mice.Cardiology, 5,0(3):175-184.

[23] YIN A, YUAN R, XIAO Q, et al.Exercise-derived peptide protects against pathological cardiac remodeling.EBioMedicine, 2,2(104164):1-21.

[24] DA ROCHA A L, TEIXEIRA G R, PINTO A P, et al.Excessive training induces molecular signs of pathologic cardiac hypertrophy.J Cell Physiol, 8,3(11):8850-8861.

[25] PUHL S L, MULLER A, WAGNER M, et al.Exercise attenuates inflammation and limits scar thinning after myocardial infarction in mice.Am J Physiol Heart Circ Physiol, 5,9(2):H345-H359.

[26] FREDERICO M J, JUSTO S L, DA LUZ G, et al.Exercise training provides cardioprotection via a reduction in reactive oxygen species in rats submitted to myocardial infarction induced by isoproterenol.Free Radic Res, 9,3(10):957-964.

[27] BITO V, DE WAARD M C, BIESMANS L, et al.Early exercise training after myocardial infarction prevents contractile but not electrical remodelling or hypertrophy.Cardiovasc Res, 0,6(1):72-81.

[28] BOZI L H, MALDONADO I R, BALDO M P, et al.Exercise training prior to myocardial infarction attenuates cardiac deterioration and cardiomyocyte dysfunction in rats.Clinics (Sao Paulo), 3,8(4):549-556.

[29] XU X, WAN W, POWERS A S, et al.Effects of exercise training on cardiac function and myocardial remodeling in post myocardial infarction rats.J Mol Cell Cardiol, 8,4(1):114-122.

[30] YENGO C M, ZIMMERMAN S D, MCCORMICK R J, et al.Exercise training post-MI favorably modifies heart extracellular matrix in the rat.Med Sci Sports Exerc, 2,4(6):1005-1012.

[31] RODRIGUES B, LIRA F S, CONSOLIM-COLOMBO F M, et al.Role of exercise training on autonomic changes and inflammatory profile induced by myocardial infarction.Mediators Inflamm, 4,4(3):1-11.

[32] MELO S F, FERNANDES T, BARAUNA V G, et al.Expression of microRNA-29 and collagen in cardiac muscle after swimming training in myocardial-infarcted rats.Cell Physiol Biochem, 4,3(3):657-669.

[33] JORGE L, RODRIGUES B, ROSA K T, et al.Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats:role in functional capacity and mortality.Eur Heart J, 1,2(7):904-912.

[34] GRANS C F, FERIANI D J, ABSSAMRA M E, et al.Resistance training after myocardial infarction in rats:its role on cardiac and autonomic function.Arq Bras Cardiol, 4,3(1):60-68.

[35] KONHILAS J P, WATSON P A, MAASS A, et al.Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy.Circ Res, 6,8(4):540-548.

[36] DEJGAARD L A, HALAND T F, LIE O H, et al.Vigorous exercise in patients with hypertrophic cardiomyopathy.Int J Cardiol, 8,0(2018):157-163.

[37] SABERI S, WHEELER M, BRAGG-GRESHAM J, et al.Effect of moderate-intensity exercise training on peak oxygen consumption in patients with hypertrophic cardiomyopathy:a randomized clinical trial.JAMA, 7,7(13):1349-1357.

[38] DELOUX R, VITIELLO D, MOUGENOT N, et al.Voluntary exercise improves cardiac function and prevents cardiac remodeling in a mouse model of dilated cardiomyopathy.Front Physiol, 7,8(899):1-8.

[39] MCMULLEN J R, AMIRAHMADI F, WOODCOCK E A, et al.Protective effects of exercise and phosphoinositide 3-kinase (p110 alpha) signaling in dilated and hypertrophic cardiomyopathy.Proc Natl Acad Sci USA, 7,4(2):612-617.

[40] STOLEN K Q, KEMPPAINEN J, KALLIOKOSKI K K, et al.Exercise training improves insulin-stimulated myocardial glucose uptake in patients with dilated cardiomyopathy.J Nucl Cardiol, 3,0(5):447-455.

[41] SABERNIAK J, HASSELBERG N E, BORGQUIST R, et al.Vigorous physical activity impairs myocardial function in patients with arrhythmogenic right ventricular cardiomyopathy and in mutation positive family members.Eur J Heart Fail, 4,6(12):1337-1344.

[42] LA GERCHE A, ROBBERECHT C, KUIPERI C, et al.Lower than expected desmosomal gene mutation prevalence in endurance athletes with complex ventricular arrhythmias of right ventricular origin.Heart, 0,6(16):1268-1274.

[43] HAFSTAD A D, BOARDMAN N, AASUM E.How exercise may amend metabolic disturbances in diabetic cardiomyopathy.Antioxid Redox Signal, 5,2(17):1587-1605.

[44] HAMBRECHT R, GIELEN S, LINKE A, et al.Effects of exercise training on left ventricular function and peripheral resistance in patients with chronic heart failure:a randomized trial.JAMA, 0,3(23):3095-3101.

[45] HAMBRECHT R, NIEBAUER J, FIEHN E, et al.Physical training in patients with stable chronic heart failure:effects on cardiorespiratory fitness and ultrastructural abnormalities of leg muscles.J Am Coll Cardiol, 5,5(6):1239-1249.

[46] COATS A J, ADAMOPOULOS S, RADAELLI A, et al.Controlled trial of physical training in chronic heart failure:exercise performance, hemodynamics, ventilation, and autonomic function.Circulation, 2,5(6):2119-2131.

[47] SANDRI M, KOZAREZ I, ADAMS V, et al.Age-related effects of exercise training on diastolic function in heart failure with reduced ejection fraction:the Leipzig exercise intervention in chronic heart failure and aging (LEICA) diastolic dysfunction study.Eur Heart J, 2,3(14):1758-1768.

[48] WISLOFF U, STOYLEN A, LOENNECHEN J P, et al.Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients:a randomized study.Circulation, 7,5(24):3086-3094.

[49] ELLINGSEN O, HALLE M, CONRAADS V, et al.High-intensity interval training in patients with heart failure with reduced ejection fraction.Circulation, 7,5(9):839-849.

[50] 王敏, 李瑾.炎性细胞在动脉粥样硬化中作用的研究进展.中国动脉硬化杂志, 2,0(3):265-270.WANG M, LI J.Progress on the role of inflammatory cells in atherosclerosis.Chin J Arterioscler, 2,0(3):265-270.

[51] 陈羽斐, 沈伟, 施海明.巨噬细胞免疫代谢与动脉粥样硬化的研究进展.中国动脉硬化杂志, 0,8(1):74-80.CHEN Y F, SHEN W, SHI H M.Advances in studies on macrophage immunometabolism and atherosclerosis.Chin J Arterioscler, 0,8(1):74-80.

[52] THOMPSON P D.Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease.Arterioscler Thromb Vasc Biol, 3,3(8):1319-1321.

[53] LIBBY P.The changing landscape of atherosclerosis.Nature, 1,2(7855):524-533.

[54] SUN Y, WU Y, JIANG Y, et al.Aerobic exercise inhibits inflammatory response in atherosclerosis via Sestrin1 protein.Exp Gerontol, 1,5(111581):5531-5565.

[55] XU Z, ZHANG M, LI X, et al.Exercise ameliorates atherosclerosis via up-regulating serum beta-hydroxybutyrate levels.Int J Mol Sci, 2,3(7):1-16.

[56] YANG J, CAO R Y, GAO R, et al.Physical exercise is a potential “medicine” for atherosclerosis.Adv Exp Med Biol, 7,9(Chapter 15):269-286.

[57] DONNELLY J E, BLAIR S N, JAKICIC J M, et al.American College of Sports Medicine position stand:appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults.Med Sci Sports Exerc, 9,1(2):459-471.

[58] SWIFT D L, MCGEE J E, EARNEST C P, et al.The effects of exercise and physical activity on weight loss and maintenance.Prog Cardiovasc Dis, 8,1(2):206-213.

[59] NEMET D.Childhood obesity, physical activity, and exercise.Pediatr Exerc Sci, 5,7(1):42-47.

[60] FONSECA-JUNIOR S J, SA C G, RODRIGUES P A, et al.Physical exercise and morbid obesity:a systematic review.Arq Bras Cir Dig, 3,6(Suppl 1):67-73.

[61] RINGSEIS R, EDER K, MOOREN F C, et al.Metabolic signals and innate immune activation in obesity and exercise.Exerc Immunol Rev, 5,1:58-68.

[62] PHYSICAL ACTIVITY GUIDELINES ADVISORY COMMITTEE REPORT 2008.To the secretary of health and human services:part A:executive summary.Nutr Rev, 9,7(2):114-120.

[63] GOODYEAR L J, KAHN B B.Exercise, glucose transport, and insulin sensitivity.Annu Rev Med, 8,9:235-261.

[64] TUOMILEHTO J, LINDSTROM J, ERIKSSON J G, et al.Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance.N Engl J Med, 1,4(18):1343-1350.

[65] COLBERG S R, SIGAL R J, FERNHALL B, et al.Exercise and type 2 diabetes:the American College of Sports Medicine and the American Diabetes Association:joint position statement executive summary.Diabetes Care, 0,3(12):2692-2696.

[66] GREGG E W, CHEN H, WAGENKNECHT L E, et al.Association of an intensive lifestyle intervention with remission of type 2 diabetes.JAMA, 2,8(23):2489-2496.

[67] GILBERT L, GROSS J, LANZI S, et al.How diet, physical activity and psychosocial well-being interact in women with gestational diabetes mellitus:an integrative review.BMC Pregnancy Childbirth, 9,9(1):60.

[68] YAMAMOTO J M, KELLETT J E, BALSELLS M, et al.Gestational diabetes mellitus and diet:a systematic review and Meta-analysis of randomized controlled trials examining the impact of modified dietary interventions on maternal glucose control and neonatal birth weight.Diabetes Care, 8,1(7):1346-1361.

[69] MUSSO G, GAMBINO R, CASSADER M, et al.A Meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease.Hepatology, 0,2(1):79-104.

[70] LABAYEN I, MEDRANO M, ARENAZA L, et al.Effects of exercise in addition to a family-based lifestyle intervention program on hepatic fat in children with overweight.Diabetes Care, 0,3(2):306-313.

[71] SLENTZ C A, BATEMAN L A, WILLIS L H, et al.Effects of aerobic vs.resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT.Am J Physiol Endocrinol Metab, 1,1(5):E1033-E1039.

[72] KEATING S E, HACKETT D A, GEORGE J, et al.Exercise and non-alcoholic fatty liver disease:a systematic review and Meta-analysis.J Hepatol, 2,7(1):157-166.

[73] RODRIGUEZ B, TORRES D M, HARRISON S A.Physical activity:an essential component of lifestyle modification in NAFLD.Nat Rev Gastroenterol Hepatol, 2,9(12):726-731.

[74] WHITSETT M, VANWAGNER L B.Physical activity as a treatment of non-alcoholic fatty liver disease:a systematic review.World J Hepatol, 5,7(16):2041-2052.

[75] HASHIDA R, KAWAGUCHI T, BEKKI M, et al.Aerobic vs.resistance exercise in non-alcoholic fatty liver disease:a systematic review.J Hepatol, 7,6(1):142-152.

[76] KEATING S E, GEORGE J, JOHNSON N A.The benefits of exercise for patients with non-alcoholic fatty liver disease.Expert Rev Gastroenterol Hepatol, 5,9(10):1247-1250.

Get Citation

FANG Wenqian, XIAO Junjie. Research progress on the effects of exercise training on cardiovascular and metabolic diseases[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2023,31(4):277-286.

Copy

Article Metrics

Abstract:1707
PDF: 2808
HTML: 0
Cited by: 0

History

Received:November 24,2021
Revised:March 31,2022
Adopted:
Online: April 06,2023
Published:

Policies & Instructions

Get Citation

Related Videos

Share

Article Metrics

History

Article QR Code