Metabolic reprogramming of immune cells in atherosclerosis

doi:10.20039/j.cnki.10073949.2023.03.006

Home > Archive>Volume 31, Issue 3, 2023 >218-224, 260. DOI:10.20039/j.cnki.10073949.2023.03.006

Metabolic reprogramming of immune cells in atherosclerosis
DOI:
                        10.20039/j.cnki.10073949.2023.03.006
                    
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                        XU Fangzhi1XU Fangzhi
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China
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DOU Lin1DOU Lin
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China
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SHEN Tao1SHEN Tao
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China
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MA Jiarui1MA Jiarui
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China
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ZUO Huiyan1ZUO Huiyan
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China
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LIU Jin2LIU Jin
Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China
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LI Jian1LI Jian
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China
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HUANG Xiuqing1HUANG Xiuqing
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China
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Affiliation:1.The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China;2.Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China)
Clc Number:R541.4
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Abstract:

Atherosclerosis is a chronic inflammatory disease characterized by lipid deposition in the arterial vessel wall, in which both innate and adaptive immune cells are involved in the disease process and play different roles. Metabolic reprogramming of these immune cells modulates disease progression by modulating immune cell phenotype and function. This article reviews the metabolic pathway changes of major immune cells associated with the course of atherosclerosis, and summarizes the types and mechanisms of metabolic reprogramming among these immune cells.

Key words:atherosclerosis; innate immune cells; adaptive immune cells; metabolic reprogramming

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XU Fangzhi, DOU Lin, SHEN Tao, MA Jiarui, ZUO Huiyan, LIU Jin, LI Jian, HUANG Xiuqing. Metabolic reprogramming of immune cells in atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2023,31(3):218-224, 260.

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Received:June 29,2022
Revised:August 24,2022
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Online: March 24,2023
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