Metabolic reprogramming:a novel mechanism of monocyte/macrophage trained immunity in atherosclerosis

doi:10.20039/j.cnki.1007-3949.2023.03.003

Home > Archive>Volume 31, Issue 3, 2023 >199-204, 244. DOI:10.20039/j.cnki.1007-3949.2023.03.003

Metabolic reprogramming:a novel mechanism of monocyte/macrophage trained immunity in atherosclerosis
DOI:
                        10.20039/j.cnki.1007-3949.2023.03.003
                    
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                        YANG Yao1YANG Yao
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China
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YAN Mingjing1,2YAN Mingjing
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China;Peking University Fifth School of Clinical Medicine, Beijing 100730, China
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XU Kun1XU Kun
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China
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SUN Shenghui1SUN Shenghui
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China
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LI Wenlin1LI Wenlin
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China
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DOU Lin1DOU Lin
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China
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HUANG Xiuqing1HUANG Xiuqing
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China
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TANG Weiqing1TANG Weiqing
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China
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LI Jian1,2LI Jian
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China;Peking University Fifth School of Clinical Medicine, Beijing 100730, China
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SHEN Tao1,2SHEN Tao
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China;Peking University Fifth School of Clinical Medicine, Beijing 100730, China
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Affiliation:1.The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China;2.Peking University Fifth School of Clinical Medicine, Beijing 100730, China)
Clc Number:R54
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Abstract:

Atherosclerosis is a chronic inflammatory disease of artery. Abnormal activation of monocytes/macrophages is closely related to the development of atherosclerosis. Recent studies have found that monocytes/macrophages can undergo metabolic reprogramming by trained immunity, promote inflammatory responses, which accelerate the progression of atherosclerosis and increase cardiovascular incidents. In this review, we discuss the function and mechanisms of metabolic reprogramming of monocytes/macrophages in the trained immunity, which may provide new therapeutic targets and methods for the prevention and treatment of atherosclerosis.

Key words:atherosclerosis; trained immunity; metabolic reprogramming; epigenetic reprogramming

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YANG Yao, YAN Mingjing, XU Kun, SUN Shenghui, LI Wenlin, DOU Lin, HUANG Xiuqing, TANG Weiqing, LI Jian, SHEN Tao. Metabolic reprogramming:a novel mechanism of monocyte/macrophage trained immunity in atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2023,31(3):199-204, 244.

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Received:June 29,2022
Revised:September 19,2022
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Online: March 24,2023
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