2025年5月24日 周六
Home > Archive>Volume 31, Issue 1, 2023 >70-79. DOI:10.20039/j.cnki.10073949.2023.01.010
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Research progress on the regulation of endothelial cells by natural products of traditional Chinese medicine in the prevention and treatment of atherosclerosis
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1.Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250000, China;2.Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250000, China)

Clc Number:

R28；R5

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    Abstract:

    Atherosclerosis (As) is the pathological basis of coronary heart disease, and vascular endothelial injury is the initiating factor of coronary atherosclerosis. Vascular endothelial cells are a single layer of cells located in the inner layer of blood vessels and regulates exchanges between the blood stream and the surrounding tissues, and their integrity is very important. Many active monomers and the derivatives in natural products of traditional Chinese medicine modulate the function of endothelial cells by intervening oxidative stress, regulating the release of vasoactive substances, reducing inflammation, and equilibrating coagulation and anticoagulant system. They have the advantages of multi-pathway, multi-link and multi-target regulation in protecting from endothelial injury and attenuating atherogenesis. They have also been used to protect against corona virus disease 2019 (COVID-19) induced endothelial injury and atheroslerosis. This article reviews the research progress of the above issues in this field.

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LEI Xueli, WANG Zhen. Research progress on the regulation of endothelial cells by natural products of traditional Chinese medicine in the prevention and treatment of atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2023,31(1):70-79.

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  • Received:May 18,2022
  • Revised:September 06,2022
  • Online: December 26,2022
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