Research progress of mechanotransduction in cardiac fibrosis

doi:10.20039/j.cnki.10073949.2023.01.004

Home > Archive>Volume 31, Issue 1, 2023 >24-33. DOI:10.20039/j.cnki.10073949.2023.01.004

Research progress of mechanotransduction in cardiac fibrosis
DOI:
                        10.20039/j.cnki.10073949.2023.01.004
                    
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                        SHI WenSHI Wen
Department of Cardiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China
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CHEN HengCHEN Heng
Department of Cardiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China
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CHEN YuxiaoCHEN Yuxiao
Department of Cardiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China
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YANG JianYANG Jian
Department of Cardiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China
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GUO XiaogangGUO Xiaogang
Department of Cardiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China
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Affiliation:Department of Cardiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China)
Clc Number:R5
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Abstract:

Cardiac fibrosis can cause cardiac diastolic and systolic disorders, induce arrhythmias, and increase the risk of hospital readmission and death in patients with cardiovascular disease. Fibroblasts are the main cell type that maintains and promotes extracellular matrix deposition in cardiac tissue and are sensitive to changes in the mechanical microenvironment. Recent studies have revealed the specific mechanical signal transduction pathways through which mechanical factors influence fibroblast function. In this review, mechanotransduction, vitro mechanical models and clinical advances are discussed.

Key words:cardiac fibrosis; mechanotransduction; fibroblast; integrin

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SHI Wen, CHEN Heng, CHEN Yuxiao, YANG Jian, GUO Xiaogang. Research progress of mechanotransduction in cardiac fibrosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2023,31(1):24-33.

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Received:April 27,2022
Revised:August 15,2022
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Online: December 26,2022
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