Dysregulation of glucose and lipid metabolism is associated with a long-term chronic low-grade inflammatory reaction, and the dysregulation of intestinal flora may be one of the main reasons for the occurrence and development of this disease and the systemic chronic inflammatory reaction. Probiotics can improve oxidative stress and inflammation levels by regulating the intestinal microenvironment and correcting imbalances in blood glucose and lipid homeostasis. As a non-drug hypoglycemic and lipid lowering method, the application of probiotics aims to provide a new vision for improving metabolic diseases and arouse more thoughts on the research, development and utilization of probiotics.