Cardiovascular disease (CVD) is a collective term for circulatory system diseases. Although CVD has made great progress in clinical research and treatment in recent decades, it is still the main disease with high morbidity and mortality in the world. Inflammation, fibrosis, etc. in CVD process promote the apoptosis of cardiomyocyte (CM), and mature CM lacks the ability to repair and regenerate after injury, which undoubtedly hinders the progress of CVD treatment.In recent years, the discovery of human induced pluripotent stem cell (hiPSC) has promoted the in vitro research of various human diseases, and provided a new direction for exploring the potential molecular mechanism of CVD. CM derived from hiPSC has provided a broad prospect for myocardial repair. In this paper, the role and research status of hiPSC in CVD are reviewed based on the related literatures in recent years.