The research progress of transient receptor potential melastatin 4 and related cardiovascular disease

doi:10.20039/j.cnki.10073949.2022.11.011

Home > Archive>Volume 30, Issue 11, 2022 >987-995. DOI:10.20039/j.cnki.10073949.2022.11.011

The research progress of transient receptor potential melastatin 4 and related cardiovascular disease
DOI:
                        10.20039/j.cnki.10073949.2022.11.011
                    
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Author:
                        FAN Hangping1,2FAN Hangping
Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China;Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China
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WANG Hongkun1,2WANG Hongkun
Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China;Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China
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WANG Xiaochen1,2WANG Xiaochen
Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China;Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China
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LIANG Ping1,2LIANG Ping
Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China;Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China
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Affiliation:1.Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China;2.Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China)
Clc Number:R363；R5
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Abstract:

Transient receptor potential melastatin 4 (TRPM4) is a Ca²＋-activated monovalent selective cation channel that also plays a key role in cardiovascular pathophysiology. TRPM4 is widely distributed in the cardiovascular system, and this channel is associated with cardiac structure and action potentials. This paper summarizes the existed studies on the physiological regulatory mechanisms of TRPM4 channel and the relationship between this channel and cardiovascular diseases, with the aim of contributing to the subsequent studies on this channel.

Key words:transient receptor potential; Ca²＋ activated non-selective cation channel; cardiovascular disease

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FAN Hangping, WANG Hongkun, WANG Xiaochen, LIANG Ping. The research progress of transient receptor potential melastatin 4 and related cardiovascular disease[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2022,30(11):987-995.

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Received:November 25,2021
Revised:April 28,2022
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Online: November 07,2022
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