Aim To evaluate the diagnostic value of serum complement C1q level in coronary heart disease. Methods Case-control studies on the diagnostic value of serum complement C1q level in coronary heart disease were collected by computer retrieval from CNKI, Wanfang, PubMed, Web of Science, Cochrane, Embase and other databases until September 2021. Meta-analysis was performed using RevMan 5.4 and Stata16.0 software. Results A total of 10 literatures met the inclusion criteria, involving a total of 2 011 subjects. Meta-analysis showed that there was no significant difference in serum complement C1q level between the coronary heart disease group and the control group(SMD=－0.9,5%CI:－0.85～0.48,P=0.58). Conclusion Serum complement C1q level may not be a diagnostic indicator of coronary heart disease.