Vascular wall stem cells and vascular remodeling-related diseases

doi:10.20039/j.cnki.10073949.2022.11.001

Home > Archive>Volume 30, Issue 11, 2022 >921-929. DOI:10.20039/j.cnki.10073949.2022.11.001

Vascular wall stem cells and vascular remodeling-related diseases
DOI:
                        10.20039/j.cnki.10073949.2022.11.001
                    
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                        CAO XuejieCAO Xuejie
Department of Physiology and Pathophysiology, School of Basic Medicine, Capital Medical University & Key Laboratory of Remodeling-related Cardiovascular Diseases, Ministry of Education, Beijing 100069, China
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TAO JiapingTAO Jiaping
Department of Physiology and Pathophysiology, School of Basic Medicine, Capital Medical University & Key Laboratory of Remodeling-related Cardiovascular Diseases, Ministry of Education, Beijing 100069, China
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QU AijuanQU Aijuan
Department of Physiology and Pathophysiology, School of Basic Medicine, Capital Medical University & Key Laboratory of Remodeling-related Cardiovascular Diseases, Ministry of Education, Beijing 100069, China
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YU BaoqiYU Baoqi
Department of Physiology and Pathophysiology, School of Basic Medicine, Capital Medical University & Key Laboratory of Remodeling-related Cardiovascular Diseases, Ministry of Education, Beijing 100069, China
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Affiliation:Department of Physiology and Pathophysiology, School of Basic Medicine, Capital Medical University & Key Laboratory of Remodeling-related Cardiovascular Diseases, Ministry of Education, Beijing 100069, China)
Clc Number:R543
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Abstract:

Vascular remodeling is the pathophysiological basis of many cardiovascular diseases such as atherosclerosis, and various cells in the blood vessel wall play an important role in this process. Among them, vascular wall stem cells, as a type of adult stem cells that exist in the vascular wall, not only participate in angiogenesis during the growth and development of the body and early adulthood, but also can be affected by pathogenic factors in adulthood, activate from dormant state, differentiate into endothelial cells and smooth muscle cells, participate in vascular remodeling after vascular injury, and affect the process of related diseases. This paper reviews the latest progress of vascular wall stem cells in vascular remodeling-related diseases, so as to provide a basis for further demonstrating the possible therapeutic potential of vascular wall stem cells.

Key words:vascular wall stem cell; vascular remodeling; vascular remodeling-related disease; atherosclerosis;endothelial cell; vascular smooth muscle cell

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CAO Xuejie, TAO Jiaping, QU Aijuan, YU Baoqi. Vascular wall stem cells and vascular remodeling-related diseases[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2022,30(11):921-929.

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Received:October 13,2021
Revised:December 07,2021
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Online: November 07,2022
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