2025年6月10日 周二
Home > Archive>Volume 30, Issue 10, 2022 >913-920. DOI:10.20039/j.cnki.1007-3949.2022.10.012
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The role of absent in melanoma 2 in atherosclerosis and abdominal aortic aneurysm
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Institute of Cardiovascular Disease ＆ Key Laboratory for Arteriosclerosis of Hunan Province, University of South China, Hengyang, Hunan 421001, China)

Clc Number:

R5；R363

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    Abstract:

    Absent in melanoma 2 (AIM2) is a member of the PYHIN (pyrin and HIN domain-containing protein) family. It senses double-stranded DNA (dsDNA) and assembles the AIM2 inflammasome. Activation of AIM2 inflammasome causes cell pyroptosis as well as the release of interleukin (IL)-1β and IL-18, thereby leading to inflammation. The AIM2 inflammasome can become activated in atherosclerotic plaque and abdominal aortic aneurysm wall, and its activation has close links to the progression of atherosclerosis and abdominal aortic aneurysm. This review will focus on the structure and function of AIM2 and its role in atherosclerosis and abdominal aortic aneurysm.

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ZHAO Zhanzhi, WU Peng. The role of absent in melanoma 2 in atherosclerosis and abdominal aortic aneurysm[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2022,30(10):913-920.

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History
  • Received:November 29,2021
  • Revised:May 11,2022
  • Online: October 09,2022
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