The role of macrophage polarization in myocardial fibrosis and related research on Notch signaling pathway

doi:10.20039/j.cnki.1007-3949.2022.10.011

Home > Archive>Volume 30, Issue 10, 2022 >905-912. DOI:10.20039/j.cnki.1007-3949.2022.10.011

The role of macrophage polarization in myocardial fibrosis and related research on Notch signaling pathway
DOI:
                        10.20039/j.cnki.1007-3949.2022.10.011
                    
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                        YANG MengYANG Meng
College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
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HU SiyuanHU Siyuan
College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
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LIANG HaoLIANG Hao
College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
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LI LinLI Lin
College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
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WANG ZiyiWANG Ziyi
College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
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YANG YangYANG Yang
College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
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HU ZhixiHU Zhixi
College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
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Affiliation:College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China)
Clc Number:R5
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Abstract:

Macrophages are a group of cells with diverse immune functions and high heterogeneity. Under the stimulation of different microenvironments, macrophages can be polarized into two subgroups:M1 and M2. There are significant differences in polarization phenotypes and function at different stages of myocardial fibrosis. That is, in the early stage of myocardial fibrosis, the proportion of M1 type increased to promote the progression of inflammation; in the later stage of myocardial fibrosis, the proportion of M2 type increased to alleviate myocardial fibrosis. The Notch signaling pathway can regulate macrophage polarization, which is related to the development of myocardial fibrosis, especially in cardiovascular diseases such as myocardial infarction and heart failure. Therefore, blocking the Notch signaling pathway is beneficial to regulating macrophage polarization, which is helpful to inhibit or reverse the process of myocardial fibrosis.

Key words:macrophage polarization; myocardial fibrosis; Notch signaling pathway

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YANG Meng, HU Siyuan, LIANG Hao, LI Lin, WANG Ziyi, YANG Yang, HU Zhixi. The role of macrophage polarization in myocardial fibrosis and related research on Notch signaling pathway[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2022,30(10):905-912.

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Received:November 23,2021
Revised:January 05,2022
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Online: October 09,2022
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