Clinical prognostic value of remnant cholesterol for MACCE in coronary heart disease patients with high-normal blood pressure
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1.The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, China;2.Dalian Ruikang Cardiovascular Hospital, Dalian, Liaoning 116086, China;3.General Hospital of Northern Theater Command, Shenyang, Liaoning 110016, China)

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R5

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    Abstract:

    Aim To investigate the predictive value of remnant cholesterol in the occurrence of major adverse cardiovascular and cerebrovascular events (MACCE) in coronary heart disease patients with high-normal blood pressure. Methods A total of 421 patients with high-normal blood pressure who underwent coronary angiography in the Department of Cardiology, General Hospital of Northern Theater Command from 2004 to 2014 were retrospectively analyzed. In this study, 97 patients with high-normal blood pressure who developed MACCE in this cohort were selected as the case group, and 97 patients with high-normal blood pressure who did not develop MACCE in the same cohort were selected as the control group by random number table for a case-control study. Results The number of patients with high-salt diet, the number of diabetic patients, the value of left ventricular end-diastolic diameter (LVEDD) and Gensini score in the case group were higher than those in the control group (which were 2.6,6.8,1.14 and 1.67 times of the control group respectively), the differences were statistically significant (P<0.05). In lipid-related indicators, the levels of remnant cholesterol, triglyceride and total cholesterol in the case group were higher than those in the control group (which were 1.1,1.38 and 1.07 times of the control group respectively), the differences were statistically significant (P<0.05). Logistic regression analysis showed that diabetes mellitus (OR=14.4,5%CI:5.13~42.89, P<0.01), high salt diet (OR=6.6,5%CI:3.00~13.90, P<0.01) and remnant cholesterol levels (OR=10.7,5%CI:2.89~35.05, P<0.01) were associated with MACCE in patients with high-normal blood pressure. The predictive value of remnant cholesterol for MACCE was evaluated by receiver operating characteristic (ROC) curve. The results showed that the area under ROC curve for remnant cholesterol to predict MACCE was 0.644 (95%CI:0.567~0.721). The optimal cut-off value was 0.52 mmol/L, and the sensitivity and specificity were 72.2% and 50.5%, respectively. Conclusion Diabetes mellitus, remnant cholesterol level and high-salt diet were independent risk factors for MACCE in patients with high-normal blood pressure, and remnant cholesterol level >0.52 mmol/L could predict the occurrence of MACCE in patients with high-normal blood pressure.

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CHEN Yan, XU Qing, ZHOU Qingzhi, Lü Zhibo, CHEN Shengyue, YOU Dejun, ZHAO Xin. Clinical prognostic value of remnant cholesterol for MACCE in coronary heart disease patients with high-normal blood pressure[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2022,30(10):878-883.

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History
  • Received:April 10,2022
  • Revised:June 11,2022
  • Online: October 09,2022
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