Research progress of ferroptosis in heart failure

doi:10.20039/j.cnki.1007-3949.2022.09.013

Home > Archive>Volume 30, Issue 9, 2022 >821-828. DOI:10.20039/j.cnki.1007-3949.2022.09.013

Research progress of ferroptosis in heart failure
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                        10.20039/j.cnki.1007-3949.2022.09.013
                    
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                        LIAO WeiLIAO Wei
Institute of Cardiovascular Disease, Hengyang Medical College, University of South China ＆ Key Laboratory for Arteriosclerology of Hunan Province ＆ Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang, Hunan 421001, China
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XIA MengdieXIA Mengdie
Institute of Cardiovascular Disease, Hengyang Medical College, University of South China ＆ Key Laboratory for Arteriosclerology of Hunan Province ＆ Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang, Hunan 421001, China
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XIANG QiongXIANG Qiong
Institute of Cardiovascular Disease, Hengyang Medical College, University of South China ＆ Key Laboratory for Arteriosclerology of Hunan Province ＆ Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang, Hunan 421001, China
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CUI YutingCUI Yuting
Institute of Cardiovascular Disease, Hengyang Medical College, University of South China ＆ Key Laboratory for Arteriosclerology of Hunan Province ＆ Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang, Hunan 421001, China
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GAN NiGAN Ni
Institute of Cardiovascular Disease, Hengyang Medical College, University of South China ＆ Key Laboratory for Arteriosclerology of Hunan Province ＆ Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang, Hunan 421001, China
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ZHOU YatingZHOU Yating
Institute of Cardiovascular Disease, Hengyang Medical College, University of South China ＆ Key Laboratory for Arteriosclerology of Hunan Province ＆ Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang, Hunan 421001, China
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PENG JuanPENG Juan
Institute of Cardiovascular Disease, Hengyang Medical College, University of South China ＆ Key Laboratory for Arteriosclerology of Hunan Province ＆ Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang, Hunan 421001, China
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Affiliation:Institute of Cardiovascular Disease, Hengyang Medical College, University of South China ＆ Key Laboratory for Arteriosclerology of Hunan Province ＆ Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang, Hunan 421001, China)
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Abstract:

Ferroptosis is a novel form of programmed cell death, characterized by intracellular iron overload-induced production of lipid peroxides and massive accumulation in cells leading to cell death. Heart failure is a serious cardiac dysfunction, and the reduction of cardiomyocytes is the main reason for its occurrence and development. Recent studies have shown that ferroptosis occurs in heart failure and confirmed that ferroptosis plays a crucial role in its pathogenesis. This article intends to review the mechanism of ferroptosis and its impact on heart failure.

Key words:ferroptosis; heart failure; cardiac remodeling; oxidative stress; mitochondrial dysfunction; iron overload

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LIAO Wei, XIA Mengdie, XIANG Qiong, CUI Yuting, GAN Ni, ZHOU Yating, PENG Juan. Research progress of ferroptosis in heart failure[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2022,30(9):821-828.

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Received:March 03,2022
Revised:April 21,2022
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Online: July 30,2022
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